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1.
Indian J Ophthalmol ; 2023 Feb; 71(2): 411-415
Article | IMSEAR | ID: sea-224822

ABSTRACT

Purpose: To evaluate the efficacy of a biosimilar ranibizumab (Razumab) on outcomes of retinopathy of prematurity (ROP) for the first time. Methods: This retrospective study included infants presenting with stage 3+ ROP either in zone 1 or zone 2 posterior or aggressive posterior ROP (APROP). All eligible infants received intravitreal razumab (0.25 mg/0.025 ml) monotherapy. Follow?up was continued monthly till complete retinal vascularization was achieved while retreatment with razumab was given when recurrent neovascularization was noted. In case of no recurrence but incomplete vascularization, laser photocoagulation was done to the residual avascular retina. Results: We included 118 eyes of 59 infants with a median gestational age of 30 weeks and median birth weight of 1250 grams. At presentation, APROP was found in 28 eyes (24%) of 14 babies while stage 3 disease was seen in zone 1 in another 28 eyes (24%) and the remaining 62 eyes (52%) had stage 3 ROP in zone 2 posterior region. Complete resolution of ROP along with complete vascularization was seen in 22 eyes (19%) at a median of 55 days (IQR = 31–56 days) and 42 eyes (35%) showed a recurrent neovascularization at a median of 51 days post razumab (IQR = 42– 55 days). The cumulative incidence of recurrence of neovascularization (21%, 95% CI = 14%–29%) peaked at seven weeks and was significantly higher in eyes with APROP (43%, 95% CI = 27%–63%) compared to eyes without APROP (13.4%, 95%CI, 8%?22%) (P < 0.001). Conclusion: Razumab appears to be safe and effective in treating ROP, with about a third requiring reinjection at seven weeks after the first dose.

2.
Article in English | IMSEAR | ID: sea-152463

ABSTRACT

Aim : To study the spectral domain optical coherence tomography (sd-oct) characteristics of macular edema in branch retinal vein occlusion. Methods : 39 patients with branch retinal vein occlusion were studied with sd-oct . Characteristics analyzed were - integrity of inner segment outer segment junction, integrity of external limiting membrane, central retinal thickness and presence or absence of serous macular detachment. Results : 30 patients had disrupted photoreceptor Inner Segment-Outer Segment integrity. ( 76.9 %). External Limiting Membrane was disrupted in 64.2 % patients ( n=25 ). Serous macular detachment was present in 20. 5% patients. Average central retinal thickness was 363.84 microns. Conclusions : Spectral domain oct characteristics can help to predict the visual outcome in patients with macular edema due to branch retinal vein occlusion.

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