ABSTRACT
Objective: To compare the mean increase in vitamin D level after treatment with daily versus monthly mega dose for long bone fracture
Methods: This study was simple randomized control trial done in Department of Orthopedic Surgery and Traumatology, Mayo Hospital, Lahore. Sample of 200 cases was collected with non-probability purposive sampling. Patients were randomized in two equal groups through lottery method. In group A, daily dose of vitamin D with Calcium and in group B; injectable monthly mega dose of 200000 IU of vitamin D with calcium were given. Patients were followed up on lst, 4th, 6th and 8th week post-operative period. Laboratory reports were assessed to measure the increase in vitamin D level in serum
Results: The mean age of patients was 27.42 +/- 10.48 years. There were 31.5% males and 68.5% females. The mean vitamin D level at baseline was 16.53 +/- 3.60mg/dl which was increased to 32.73 +/- 4.57ng/dl after 4 weeks. The mean increase in vitamin D level in daily dose groups was noted as 14.31 +/- 2.22ng/dl whereas the mean value in Monthly dose group was noted as 18.17 +/- 2.27ng/dl, 9p-value=0.000]
Conclusions: The study results showed that monthly mega dose of vitamin D is more effective and beneficial as compared to daily slow dose