X-ray induced changes in the epidermis of guinea pigs-a morphometeric study

Measurement of changes in the thickness of epidermis of different locations in guinea pigs after single dose X-ray irradjation. A prospective experimental study. Department of Anatomy, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre Karachi from 2008 to 2009. Thirty animals were taken and divided into two groups which were subdivided into three subgroups containing five animals each, according to the time of sacrifice i.e. 48 hours, 15[th] day and 45[th] day respectively. A single whole body x-radiation in a dose of 5 Gy. Animals were sacrificed under ether anaesthesia after completion of their respective period. Tissues were processed and 4 to 5 micron thick paraffin embedded sections were cut, and stained with H and E. Desquamation and decrease in thickness of epidermis was present after 48 hours which shows highly significant result when compared to control [P- < 0.001]. After wards progressively increase in hyperkeratinization was noted after 15 days which is nonsignificant [P- >0.05] when compared to control. After 45[th] day proliferation of basal cells occurred which increased the thickness of epidermis near to control. The study concludes that x-radiation produces deterministic epidermal changes in all three sites i.e. face, abdomen and back of guinea pigs

experimental status of fine needle aspiration cytology of head and neck lesions in a tertiary care scenario

Fine Needle Aspiration Cytology being a minimally invasive technique, is particularly suitable in the sensitive head and neck area where an incisional biopsy may cause problems. FNAC can obviate the need for surgery if the lesion is shown to be non neoplastic or if it confirms suspected metastatic or recurrent tumor. A preoperative cytological diagnosis of a primary neoplasm may allow more rational planning of surgery. This descriptive observational study was carried out at the Department of pathology, DDRRL Dow University of Health Sciences and Sindh Government Qatar hospital during the year 2008-09. A total of 518 consecutive FNAC's of head and neck lesions were included. Out of this 356 cases were from cervical lymphnodes, 124 cases were from thyroid and 38 cases from salivary glands. A total of 45 cases were found malignant and 473 cases were reported as benign lesions

Para-testicular rhabdomyosarcoma

We are presenting the case report of a young male, aged 19 years, who presented with a scrotal swelling and loss of weight and was ultimately diagnosed to have a rare tumour viz. Para-testicular rhabdomyosarcoma