ABSTRACT
Objective: To compare the mean duration of atracurium induced neuromuscular blockade in minutes when dosed according to real body weight [RBW] or ideal body weight [IBW] to obese patients undergoing abdominal surgeries under general anesthesia
Study Design: Randomized controlled trial
Place and Duration of Study: Department of Anesthesiology, National hospital defense Lahore, From March 2015 to March 2016
Material and Methods: One hundred and fifty [150] patients were selected for this study and divided in to two equal groups [75 patients in each group], group-I [experimental group] and group-II [control group]. Sample size was calculated with 80% power of test, 95% confidence interval taking mean and standard deviation of duration of atracurium induced neuromuscular blockade in minutes in both groups i.e. 74.6 +/- 37.56 in real body weight group versus 40.02 +/- 22.5 in ideal body weight group. Non probability consecutive sampling technique was used. SPSS version 16 was used for data analysis. Frequency and percentages were used to present categorical data and mean +/- standard deviation for numerical data. Independent sample t-test was applied to compare the significance of outcome variables. A p-value of <0.05 was considered statistically significant
Results: There was a prolong duration of action in experimental group [real body weight group] 69.64 +/- 3.11 minute versus 46.33 +/- 2.77 minute in control group [ideal body weight group] which suggests that dose of atracurium should be calculated and given on basis of ideal body weight in obese
Conclusion: It was observed in our clinical trial that body weight calculation and dosage of atracurium accordingly has altered duration for recovery from blockade, the results of the study showed that atracurium when used according to ideal body weight as compared to total body weight has reduced duration of action. So atracurium dose should be calculated according to ideal body weight rather than total body weight in obese patients
ABSTRACT
Objective: to compare conventional Macintosh laryngoscope with Airtraq for elective tracheal Intubation
Material and Methods: a in this randomized control trial conducted during Jan-June 2013. 50 ASA I andII patients without predicted difficult airway included in each group. Main outcomes were intubation time and intubation success rate, number of attempts, airway injury, and number of optimization maneuvers, glottic view and failure of intubation
Results: airtraq has significantly less intubation time, number of optimization maneuvers required and better glottic view [p<0.005] as compared to Macintosh laryngoscope
Conclusion: during elective intubation, Airtraq has better laryngoscopic view and shorter intubation time as compared to Macintosh laryngoscope