ABSTRACT
Currently available treatment options fail to maintain glycemic control over long time and are accompanied by various side effects. Therefore, there is a need to develop newer treatment strategies such as hypoglycemic agents of plant origin as they are known to have fewer side effects. Several herbal preparations are used to treat diabetes, but their reported hypoglycemic effects are complex. The study was conducted on 35 healthy rabbits of either sex following administration of Cassia italica plant extract for a period of 14 days. Present study provides evaluation of hypoglycemic effect of Cassia italica in the alloxan induced diabetes rabbits along with comparative hypoglycemic efficacy of glibenclamide. Results reveals that 100 mg/kg oral dose of plant extract did not cause significant changes in blood glucose level however results of plant extract at the dose of 200 mg/kg were similar to glibenclamide at the dose of 2.5mg/kg body weight, however result of the present study can only be confirmed after evaluating Cassia italica on large number of animals as well as clinically