ABSTRACT
To study the effect of breast cancer treatment on liver enzymes in diabetic and cardiac breast cancer females. Cross-sectional type of study. Liaquat National Hospital Karachi. January 2008 to January 2010. Total 47 breast cancer patients. Out of these, 22 were diabetic and 25 were cardiac patients, visiting the oncology OPD of the hospital. Patients with metastasis to distant organs were excluded from the study. Treatment was carried under the supervision of an oncologist. Samples were collected twice during the study. First sample was collected at disease presentation before starting any type of treatment and second time, sample was collected 14 weeks after the last chemotherapy dose. Data was analyzed using statistical package [SPSS version 11.0]. "Students t-test" and analysis of variance [ANOVA] was used to analyze the means and standard deviations of quantitative/continuous variables. In all statistical analysis p<0.05 was considered significant. In all patient groups after treatment alkaline phosphatase was significantly high as compared to that before treatment [p<0.05] whereas alanine transaminase increased significantly without including Tamoxifen in the treatment. Variation pattern of liver enzyme was the same in both patient groups. Altered profile of liver enzyme was similar in both patient groups there for the variations cannot be attributed to hyperglycemia in diabetic females and the alterations in liver enzymes were attributed to liver damage by chemotherapy and fatty infiltration of liver induced by Tamoxifen
ABSTRACT
Objective: To find out frequency of tea use with possible health effects in urban population of Hyderabad Sindh
Place and duration: At Department of Pharmacology and Therapeutics, Liaquat University of Medical and Health Sciences Jamshoro from 1[st] March 2010 to 30[th] April 2010
Study design: A cross sectional study
Methodology: The study was performed on 1432 healthy individuals. The baseline demographic characteristics were recorded on a specially designed proforma. The socioeconomic status was divided in five categories according to monthly earnings. Consumption of tea was estimated by the number of cups/day and type of tea consumed. Sugar added to tea was calculated by the number of teaspoons. Waist to hip ratio was also calculated. Persons with history of chronic diseases were excluded from the study
Results: 1102 males and 330 females participated in the study [n=1432], the mean age for men was 38+1.54 years and for women it was 30+1.25years. Among the 1102 males, 22.68% consumed 5-6 cups/day, 58.98% 3-4 cups/day and 18.33% only 2 cups/day, while females when inquired only 22% were consuming 2 cups/day with 48.48% 3-4cup/day and 31.5% were having 5-6 cups/day. Tea was prepared mostly by adding milk. 805 [73.04%] males and 250 [75.7%] females were having such tea, while only 3.62% of males 3.03% females were using black tea. The habit of having green tea was seen in 257 [23.32%] males, while none of the females in the present research was using green tea. Socioeconomically most of the participants belonged to lower socio economic group [Table - I] earning 3000-9000 rupees / month [36.47% males and 39.3% females]: Waist to hip ratio was positively correlated with the amount of sugar and frequency of tea intake
Conclusion: Tea can be hazardous for health if the pattern continues to be same, so habit of green tea ingestion should be encouraged as tea mixed with milk and sugar further adds to the burden of future diabetics
ABSTRACT
OBJECTIVE: To find out the correlation between Chronic Idiopathic Urticaria and H.pylori infection and to observe the effect of Eradication therapy
STUDY DESIGN: Observational study
MATERIALS AND METHODS: 20 patients giving history of Chronic Idiopathic Urticaria were enrolled in the study. Serological testing for the presence of H. pylori infection done and were given eradication therapy [Capsule Esomeprazole 40 mg o.d, Tablet Metronidazole 400 mg t.d.s and Tablet Clarithromycin 500 mg b.i.d] for a period of 2 weeks. Clinical assessment was done at day 0, 30, 60, 90 and 120 by a scoring system [symptom evaluation scale], H.pylori status was reassessed at day 60 to confirm eradication effectiveness or to see any relapse of symptoms
SETTING: The study was conducted by the Department of Pharmacology and Therapeutics, BMSI, JPMC with the collaboration of Department of Dermatology JPMC Karachi from May 2008 to August 2008
RESULTS: Among 20 patients, 19 were positive for H.pylori infection and were given eradication therapy. Eradication therapy was successful in 18 patients one patient could not complete the study and there was relapse in one patient The mean SES scores decreased from 3.73 +/- 0.45 on day 0 to 2.52 +/- 0.51 on day 30, 1.52 +/-0.51 on day 60, 1.15 +/- 0.51 on days 90 and 0.47 +/- 0.77 on day 120. A percentage change of 59.13% was observed with a p value of <0.002
CONCLUSION: There is a possible role of H.pylori infection in pathogenesis of chronic idiopathic Urticaria
ABSTRACT
Joshanda which, a polyherbal preparation is extensively used by masses as a household remedy for treatment of common cold and found very effective. Our results indicated that Zizyphus jujube [Unnab], Onosma bracteatum [Gaozaban] and glycyrrhiza glabra [Mulethi] have significant degree of invitro activity against Staph. aureus while Cordia latifolia [Sapistan] has got a significant invitro activity against H.influenzae. Other ingredients did not show any significant activity against rest of the organisms tested