ABSTRACT
Background: Various treatments have been proposed to treat ectopic pregnancy, but their impact on future pregnancies is still the subject of controversy
Objective: The aim of this study is to compare the medical and surgical treatment methods and their impact on the subsequent fertility results and complications in women with a history of ectopic pregnancy
Materials and Methods: In this analytical, cross-sectional study, 370 women with the history of ectopic pregnancy, [treared with single dose of methotrexate or salpingectomy by laparotomy], that referred to Al-Zahra Hospital, Rasht, Guilan between 2009 to 2013 were enrolled. 147 women responded to the phone call. The age, the number of women that needed to drug for pregnancy, fertility rate and the fertility outcomes were studied
Result: 147 women responded to the call and between them, 114 women tried to get pregnant again after the ectopic pregnancy treatment. They were agreed to the participate in the study. The mean age of the patients was 28.56 +/- 5.63 yr. The fertility rates in the medical and the surgical groups were 56.6% and 47.61%, respectively [p=0.141]. There were no significant differences in the poor consequences of pregnancy among the two groups; ectopic pregnancy [p=0.605], miscarriage [p=0.605], and prematuredelivery [p=0.648]. 15.1% in the medicinal group and two patients 12.5% in the surgical group had received fertility treatment in order to get pregnant [p=0.135]. There was no significant difference in two groups
Conclusion: It seems that surgical treatment depending on the underlying variables of each patient, can be used such as medical treatment, without worrying about its effect on fertility
ABSTRACT
Hypertensive disorders [HDs] as the most prevalent medical problem during pregnancy, predispose the patient to a lot of comorbidities and may even cause maternal or fetal death. The rate of infertility has been increasing in recent decades. So, we collected and summarized data about the co-existence of these two entities and found that HDs are somewhat more common in women receiving fertility treatments regardless of pathophysiologic correlation of infer- tility and hypertension or older age and chance of multiple pregnancies
ABSTRACT
Background: Ovarian hyperstimulation syndrome [OHSS] is one of the most important complications of assisted reproduction treatment. Many substances are involved in the regulation of the vascular permeability, which have been concerned to cause OHSS. Vascular endothelial growth factor [VEGF] has emerged as one of the main angiogenic factors, which could be responsible for increased vascular permeability
Objective: In this study the association of vascular endothelial growth factor -460C/T and +405 G/C polymorphisms and susceptibility to ovarian hyperstimulation syndrome was evaluated
Materials and Methods: In this cross sectional study, VEGF gene polymorphisms were amplified by Polymerase chain reaction- Restriction Fragment Length Polymorphism in 75 women with established OHSS [case group] and 85 normoresponder [control group] which received conventional ovarian stimulation regimen
Results: There was no significant difference in the frequency of -460 C/T polymorphism between cases and controls [p=0.85]. The frequency of +405 G/C polymorphism was significantly higher in the OHSS women [p=0.03, OR=2.44; 95% CI=1.23-4.82]
Conclusion: In women who developed OHSS, VEGF gene polymorphism +405 could be effective. Two of the polymorphisms -460 C/T and +405 G/C were reported to be associated with increased VEGF basal promoter activity. However, only +405 G/C gene polymorphisms were more frequent in cases than controls
ABSTRACT
Background: Gestational trophoblastic neoplasia [GTN] is a curable disease that involves the development of malignant tumor in the woman after a normal or molar pregnancy. The position of surgery in GTN is not properly specified and is changing due to new chemotherapy protocols. However, the role of surgery is highlighted in chemotherapy-resistant GTN. Other indications of surgery in trophoblastic diseases are drug toxicity and uterine perforation. Based on the fact that most women in certain age tend to preserve fertility, this study reported 4 cases of successful treatment after fertility sparing surgery
Case: A hospital-based case-report study was carried out to investigate the role of surgery in 4 patients with GTN. In this study, acute complications, such as intraabdominal bleeding and liver dysfunction due to chemotherapy occurred in some patients. Surgery was performed and all cases underwent localized tumor removal while preserving the uterus. No hysterectomy surgery was performed
Conclusion: Surgery is supposed in specific cases of GTN, who desire preserving fertility