ABSTRACT
Objective: to see the effects of aspartame during 9 weeks with 100,250 and 500 mg/kg/body weight dose of aspartame on: 1. liver weight index in Albino mice. 2. Sinusoids, central and portal veins in mice liver
Material and Methods: it is an experimental study, which was placed in Anatomy Department of Post Graduate Medical Institute, Lahore. 44 Albino mice were divided equally in four groups A, B, C and D [11 animals each]. Group A was the control group. Groups B, C and D were experimental group's and given aspartame in a dose of 500 mg/ kg/ b.w for 3, 6 and 9 weeks respectively. Aspartame was given orally by gavage method
Results: aspartame reduced body weight, provoked statistical significant increase in liver weight index with increased dose. Congestion and dilation was observed in sinusoids, portal and hepatic veins with increased dose
Conclusion: although aspartame is used for weight loss but its excessive use may lead to hepatic damage
ABSTRACT
Finasteride, a synthetic 4-azasteroid compound, is a specific inhibitor of steroid Type II 5 alpha-reductase, which belongs to one of a new class of drugs that is potentially useful in treating androgenetic alopecia [male pattern baldness], hirsutism and possibly acne
Objectives: To evaluate the effects of Finasteride on albino rat hepatocyte diameters
Materials and Methods: 52 male albino rats were randomly divided into two equal groups A [which was control] and B [which was experimental]. Group B animals were given Finasteride 80 mg/kg body weight between 10-11 am, [provided by FEROZESONS laboratories] dissolved in normal saline, for 30 days through naso-gastric tube. The animals of the control group were given only normal saline through naso-gastric tube for the same period of time. Twenty four hours after the cessation of treatment Livers were collected from the rats of both groups after dissection. 10% Formalin solution was used to fix the liver. 5 micro m serial sections of liver were cut and stained with haematoxylin/eosin stains for detailed histological study of hepatocytes
Results: It was observed that in experimental group the diameter of hepatocytes was increased as compared with control group [p-value <0.001]
Conclusion: Finasteride was responsible for mild hepatocellular injury showing increase in the diameter of the hepatocytes