ABSTRACT
This study attempts to highlight the relation of various types of cancers to abnormalities in liver and renal function tests. Correlation of deranged renal and liver function tests to different types of cancers in industrial workers who are exposed to industrial chemicals and carcinogens. This non-interventional study included 100 hundred confirmed cases of cancer were selected and studied from July 2011 to December 2011. The study was conducted at Fatima Memorial Hospital/College of Medicine and Dentistry, Lahore. Out of these 100 patients, 21 had CA lung, 19 had lymphoma, 14 had sarcoma, 13 had CA breast, 6 had CA prostate, 4 had CA liver, 3 had CA colon, 3 had CA ovary, 3 had CA testis, 2 had leukemia, 2 had multiple myeloma, 2 had CA gall bladder, 2 had CA stomach, 1 had CA esophagus, 1had CA tongue, 1had CA parotid, 1 had CA rectum, 1 had CA cervix and 1 had CA larynx. Among lymphoma, non-Hodgkin lymphoma was more than Hodgkin lymphoma [out of 19 patients, 13 had non-Hodgkin and 6 had Hodgkin lymphoma]. Out of 14 patients of sarcomas, 5 had Ewing sarcoma, 4 had chondrosarcoma, 3 had fibrosarcoma and 2 had liposarcoma. Similarly the serum bilirubin levels in liver cancer, ovarian cancer, multiple myeloma, stomach and gall bladder cancer were 1.50 +/- 0.31, 1.17 +/- 0.10, 1.46 +/- 0.15 and 1.40 +/- 0.50 mg% were 32.38 +/- 18.81, 37.73 +/- 4.35, 34.43 +/- 4.35, 45.00 +/- 46.17, 31.33 +/- 44.70, 65.25 +/- 31.14, 33.67 +/- 80.90, 99.00 +/- 73.08, 50.00 +/- 98.49, 33.50 +/- 75.0, 36.50 +/- 85.0 and 49.0 +/- 11.0 micro /l respectively which were statistically significantly higher [p<0.05] then control individuals. respectively which were significantly higher [p<0.05] than the control individuals Similarly the ALT levels in lung cancer, lymphoma, sarcoma, breast cancer, prostate cancer, liver cancer, leukemia, ovarian cancer, cancer of colon, multiple myeloma, cancer of testis and stomach. The mean serum creatinine levels in lung cancer, liver cancer and cancer of colon were 0.89 +/- 0.05, 0.90 +/- 0.16 mg% respectively which were significantly higher than the control individuals [p<0.05]. The renal and liver function tests should be frequently monitored in cancer patients from industrial back grounds