ABSTRACT
So far known Andrographis paniculata Nees (AP) is a hepatoprotective, antiplatelet and antithrombotic drug. In this experiment its hypoglycaemic effect has been tried in various way. Water extract of AP 10 mg/kg body weight can prevent induction of hyperglycaemia significantly (P < 0.001) induced by oral administration of glucose 2 mg/kg body weight. But any how failed to do so in adrenaline induced hyperglycaemia. It also failed to demonstrate any "fasting blood sugar lowering effect" upon chronic administration (6 weeks) of AP. So probably AP prevents glucose absorption from gut. Whole experiment was done on rabbits.
Subject(s)
Animals , Anticoagulants/pharmacology , Blood Glucose/analysis , Female , Hypoglycemia/chemically induced , Male , Plants, Medicinal , Platelet Aggregation Inhibitors/pharmacology , RabbitsABSTRACT
Six weeks old male and female mice belonging to Wister strain were put on diets supplemented to the extent of 0.75% by the powdered stem of A. peniculata Nees for one, two, three and four weeks and the effect on fertility and gestational period was observed. Significant reduction in fertility was observed after three and four weeks of feeding in the group containing the treated males and the untreated females. In the same group the gestation period was also prolonged after four weeks of feeding. There was virtually no change in fertility and gestational period in the treated females and the untreated males during any stage of the experiment.