ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical characteristics, pathological and biological behaviors of oral squamous cell carcinomas (OSCC) originated from oral submucous fibrosis (OSF).</p><p><b>METHODS</b>A total of 528 patients with OSCC treated at Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University from 2002 to 2010 were divided into two groups, OSCC originated from OSF and OSCC not originated from OSF. The clinical data regarding age, gender, location, pathological type, metastasis and recurrence rate of these patients were analyzed retrospectively.</p><p><b>RESULTS</b>The mean age of the group of OSCC originated from OSF (45.8 years) was younger than that of the group of OSCC not originated from OSF (55.9 years). The male female ratio of the group of OSCC originated from OSF (32.3:1) was higher than that of the group of OSCC not originated from OSF (2.3:1). The metastasis and recurrence rate of the group of OSCC originated from OSF (13.5%, 39.1%) was higher than that of the group of OSCC not originated from OSF (7.6%, 27.8%.).</p><p><b>CONCLUSIONS</b>OSCC originated from OSF occurs at younger age and more in male, and is clinically more invasive and metastatic.</p>
Subject(s)
Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Age Factors , Carcinoma, Squamous Cell , Pathology , Cell Transformation, Neoplastic , Pathology , Follow-Up Studies , Lymphatic Metastasis , Mouth Neoplasms , Pathology , Neoplasm Recurrence, Local , Neoplasm Staging , Oral Submucous Fibrosis , Pathology , Retrospective Studies , Sex FactorsABSTRACT
<p><b>OBJECTIVE</b>To determine the expression of Cyclin B1, p34(cdc2) and the phosphorylation of survivin (p-survivin) in oral squamous cell carcinoma and oral submucosa fibrosis (OSF), and to discuss their possible role in carcinogenesis of OSF.</p><p><b>METHODS</b>The expression of Cyclin B1, p34(cdc2) and p-survivin were analyzed by Western blotting assay in 10 cases of normal oral mucosa epithelium, 40 cases of OSF epithelium and 42 cases of oral squamous cell carcinoma (OSCC) originated from OSF, respectively. Immunoprecipitation was used to confirm the relationship between the p34(cdc2) and survivin.</p><p><b>RESULTS</b>The expression of Cyclin B1, p34(cdc2), p-p34(cdc2) and p-survivin in OSF group were significantly higher than those in normal group (P < 0.05). The expression of these molecules showed significant different (P < 0.05) between the OSF and OSCC originated from OSF, but there was no significant difference among the early stage, the moderately advanced stage and the advanced stage of OSF. Immunoprecipitation assay confirmed the combination of p34(cdc2) and survivin.</p><p><b>CONCLUSIONS</b>The important molecules in G(2)/M phase-Cyclin B1, p34(cdc2) and p-survivin may play a key role during the mitosis and proliferation of OSF, which will be helpful in early diagnosis and therapy of carcinogenesis of OSF.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , CDC2 Protein Kinase , Metabolism , Carcinoma, Squamous Cell , Metabolism , Pathology , Case-Control Studies , Cell Division , Cyclin B1 , Metabolism , G2 Phase , Inhibitor of Apoptosis Proteins , Microtubule-Associated Proteins , Metabolism , Mouth Neoplasms , Metabolism , Pathology , Neoplasm Staging , Oral Submucous Fibrosis , Metabolism , Pathology , PhosphorylationABSTRACT
Nevoid basal cell carcinoma syndrome is a rare autosomal dominant genetic disorder characterized by developmental abnormalities and tumorigenesis. In this paper, a case of nevoid basal cell carcinoma syndrome family was reported, and its incidence, pathogenesis, clinical features and methods of treatment were discussed by reviewing relevant literatures.