ABSTRACT
With the development of cardiothoracic surgery, anesthesia, myocardial protection and in vitro technique, the management of congenital heart disease has gradually become younger and lower, and the nursing management of the postoperative system plays an important role. The purpose of this study was to analyze the causes of malnutrition in children with congenital heart disease<6 kg, the significance of postoperative enteral nutrition support, nutritional assessment, oral feeding and tube feeding. Postoperative enteral nutrition support in children with congenital heart disease provides the most appropriate and accurate care, reduce the incidence of complications, optimize their quality of life and postoperative outcome.
ABSTRACT
Objective To investigate the effect of gabapentin on high voltage active calcium currents in the injured dorsal root ganglion (DRG) neurons in a rat model of neuropathic pain.Methods Pathogen-free male SD rats aged 4-6 weeks were used in this study. The animals were anesthetized with intraperitoneal pentobarbital soclium 50 mg/kg. L_5 spinal nerve was ligated between DRG and sciatic nerve and cut distal to the ligature. The animals were decapitated on the 14th postoperative day. L_5 DRG was isolated and the neurons in the ganglion were enzymatically dissociated. The high voltage active calcium current was recorded using whole-cell patch-clamp technique.Results Gabapentin inhibited the peak calcium current in the injured DEG neurons. Peak calcium current was decreased by gabapentin 100 μmol/L and both activation and steady-state inactivation curve shifted to more hyperpolarized potentials. Conclusion Gabapentin can inhibit high voltage active in the injured DRG neurons in a rat model of neuropathic pain. The alteration in the inactivation of the electrophysiological properties may be involved in the mechanism.