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Objective To investigate and analyze the health literacy and nutritional characteristics of maintenance hemodialysis (MHD) patients with diabetes mellitus in Huizhou, and to analyze its influencing factors. Methods MHD patients with treatment time ≥ 3 mon in Huizhou from January 2016 to December 2019 were enrolled, including 320 patients with diabetic nephropathy and 320 patients with simple nephropathy. Demographic characteristics, health literacy level and nutritional status of all patients were collected to analyze the risk factors affecting the health and nutrition status of patients. Results The proportion of subjects with healthy living habits, nutritional knowledge, health literacy, normal Hb and ALB levels among diabetic nephropathy patients was lower than that of patients with simple nephropathy ( P < 0.05 ). Age ≥ 55 years old, education level below junior high school, irregular living habits, and ignorance of nutrition knowledge were the independent influencing factors for diabetic nephropathy patients without health literacy (P<0.05). Age ≥55 years, dialysis duration ≥5 years, treatment interruption, irregular health habits, and lack of health literacy were independent influencing factors for abnormal nutritional status in diabetic nephropathy patients ( P < 0.05 ). Conclusion The health literacy and nutritional characteristics of MHD patients in Huizhou were worse than those of patients with nephropathy, which were mainly related to age, education level, living habits, and dialysis treatment.
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<p><b>OBJECTIVE</b>To explore the predictive factors of sensitivity to preoperative concomitant radiochemotherapy for the local mid-low advanced rectal cancer in order to guide the individualized therapy.</p><p><b>METHODS</b>Clinicopathologic data of 44 patients with local mid-low advanced rectal cancer receiving preoperational concomitant radiochemotherapy were retrospectively analyzed. Expression of epidemical growth factor receptor (EGFR) in biopsy specimen was detected with SP immunohistochemistry (IHC). Downstaging of tumor TNM stage and tumor regression grade (TRG) after radiochemotherapy were used as the standards of sensitivity to preoperational concomitant radiochemotherapy. Association of EGFR expression and pathological change with clinicopathological data before radiochemotherapy (gender, age, pathological type, tumor TNM stage, serum CEA, CA199, radiation method, etc) was analyzed.</p><p><b>RESULTS</b>Percentage of downstaging of tumor TNM stage and 3-4 TRG in patients with negative or weak positive EGFR expression was significantly higher as compared to those with strong and moderate positive EGFR expression [86.7% (13/15) vs. 30.4% (7/23), P<0.01; 80.0% (12/15) vs. 8.7% (2/23), P<0.01]. Percentage of downstaging of tumor TNM stage and 3-4 TRG in patients with tubular adenocarcinoma was significantly higher as compared to those with mucous adenocarcinoma [61.8% (21/34) vs. 10.0% (1/10), P<0.01; 47.1 (16/34) vs. 0 (0/10), P<0.01]. EGFR expression was not associated with pathological type (P>0.05). Sensitivity to preoperative concomitant radiochemotherapy was not associated with age, gender, tumor stage, tumor differentiation, serum CEA, serum CA199 and radiation method (all P>0.05).</p><p><b>CONCLUSIONS</b>Pathological type and EGFR expression level may be two independent predictive markers of sensitivity to preoperative concomitant radiochemotherapy for patients with rectal cancer. Patients with tubular adenocarcinoma or low EGFR expression in tumor tissue may be more sensitive to concomitant radiochemotherapy.</p>
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Adolescent , Adult , Aged , Female , Humans , Male , Middle Aged , Young Adult , Chemoradiotherapy , Neoplasm Staging , Preoperative Care , ErbB Receptors , Metabolism , Rectal Neoplasms , Therapeutics , Retrospective StudiesABSTRACT
Objective To assess the efficacy of sandostatin in preventing postoperative adhesions in rats. Methods Fifty SD rats were randomly divided into five groups: Group 1, Control group; group 2, sandostatin 20μg/kg intraperitoneal injection (IP); group 3, sandostastin 40μg/kg IP; group 4, sandostatin 60μg/kg IP; group 5, hyaluronate sodium(HA) IP. All animal were killed on the 14th postoperative day. After adhesions were graded according to their severity, adhesive ileal segments were resected for hydroxyproline(OHP) determination. Results The severity of adhesions in group 2.3.4 and 5 were significantly milder than that in group 1.(P<0.05). The OHP levels of adhensive intestine in group 2.3 and 4 were significantly lower than that in group 1 and 5 (P<0.05).The severity of adhesions and OHP levels in group 2.3 and 4 had no significant difference (P>0.05). Conclusions Intraperitoneal administration of sandostatin intraoperatively might have some efficacy in preventing adhensions of intestine.
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Objective To study the optimal procedure of digestive tract reconstruction after total gastrectomy.Methods The clinical data of 122 patients who underwent total gastrectomy in the recent 6 years were(analyzed) retrospectively.Three types of reconstruction procedures,including Orr-type Roux-en-Y(esophagojejunostomy),P-type jejunal pouch Roux-en-Y esophagojejunostomy and distal jejunal aboral pouch Roux-en-Y esophagojejunostomy,were performed.Results There were no significant differences among the three procedures in heartburn and the amount of food intake,frequencies of meal,weight loss,dumping(syndrome),and hemoglobin and albumin levels.The operation time in P-type group was longer than the other two group(P