Efficacy and safety of domestic olmesartan in treatment of mild to moderate essential hypertension / 上海交通大学学报（医学版）

Objective To evaluate the efficacy and safety of domestic olmesartan in treatment of mild to moderate essential hypertension in comparison with losartan. Methods Two hundred and thirty-seven patients with mild to moderate essential hypertension were enrolled in a randomized, double-blind, multi-center, paralleded and active-controlled trial, and were divided into olmesartan group (olmesartan 20 mg + losartan 50 mg placebo) and losartan group (losartan 50 mg + olmesartan 20 mg placebo) for a 8-week therapy. Four weeks after treatment, dosages of drugs were doubled in patients with seated diastolic blood pressure ≥90 mmHg (1 mmHg =0.133 kPa). All patients were followed up every two weeks, and the efficacy and adverse effects were observed. Another 32 patients with mild to moderate essential hypertension were enrolled and given olmesartan only, and ambulatory blood pressure monitoring was performed before and 8 weeks after treatment. Results Compared with those before treatment, both systolic blood pressure and diastolic blood pressure significantly decreased in olmesartan group and losartan group 8 weeks after treatment [(15.2 ±13.3) mmHg and (19.5 ±11.8) mmHg, respectively for systolic blood pressure (P <0.001); (15.9 ±7.48) mmHg and (16.2 ± 5.95) mmHg, respectively for diastolic blood pressure (P < 0.01) ], while there was no significant difference between these two groups (P > 0.05). There was no significant difference in total effective rate and incidence of adverse effect between these two groups (86.9% vs 93.7% and 7.63% vs 5.88% , P > 0.05) . Ambulatory blood pressure monitoring demonstrated that trough to peak ratios of systolic blood pressure and diastolic blood pressure were 86% and 71%, respectively. Conclusion Domestic olmesaratan provides an effective, safe and long action in the treatment of mild to moderate essential hypertension.

Effect of Atenolol on the Pharmacokinetics of Nitrendipine in Healthy Volunteers / 中国药房

0.05).CONCLUSION:Single oral dose of atenolol had no significant effect on the pharmacokinetics of nitrendipine.

Detection of Siderophore from Halophilic Archaea with Two-layer Plate / 微生物学通报

A two-layer plate was developed for in situ detection of siderophore from halophilic archaea. Halophilic archaea could grow on the upper nutrient layer without addition of iron and excrete siderophore under iron-limited stress.The lower layer was the detection agar,which contained universal blue-coloured ferric-CAS complex.The presence of the siderophore was indicated by the decolorization of the blue complex, resulting in a yellow-orange halo around colonies growing on the upper nutrient layer,when the excreted siderophore penetrated from the upper nutrient layer into the lower detection agar.The results showed that the two-layer plate method was applicable to the detection of siderophore from halophilic archaea, which was more convenient and definite than former approach for halophilic archaea siderophore detection.