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Abstract Present study analysed the therapeutic potential of traditionally acclaimed medicinal herb Nanorrhinum ramosissimum, using plant parts extracted with different solvents (10 mg/mL). Shoot extracts exhibited comparatively better antimicrobial properties, in comparison to root extracts. Total phenolic content was estimated, to ascertain its dependency on antioxidant properties of plant extracts. Antioxidant assay revealed promising results in comparison to IC50 value of standard ascorbic acid (52.2±0.07 µg/mL), for methanolic extracts of shoot (61.07±0.53 µg/mL and 64.33±0.33 µg/mL) and root (76.705±0.12 µg/mL and 89.73±0.28 µg/ mL) for in vivo and in vitro regenerants respectively. Correlation coefficient R2 values ranged between 0.90-0.95, indicating a positive correlation between phenolic contents and antioxidant activity. Plant extracts were also able to inhibit DNA oxidative damage again indicating their antioxidative potential. Antidiabetic potential was confirmed by alpha amylase inhibition assay where shoot methanolic extracts (invivo, in vitro) exhibited the best IC50 values (54.42±0.16 µg/mL, 66.09±0.12 µg/mL) in comparison to standard metformin (41.92±0.08 µg/mL). Ethanolic extracts of roots (in vitro, invivo) exhibited the relative IC50 values (88.97±0.32µg/mL,96.63±0.44 µg/mL) indicating that shoot parts had a better alpha amylase inhibition property; thus proving the herb's bioactive potential and its prospective therapeutic source for curing various ailments.
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Plants, Medicinal/adverse effects , Plant Extracts/analysis , Scrophulariaceae/classification , Antioxidants/pharmacology , In Vitro Techniques/methods , Hypoglycemic Agents/agonistsABSTRACT
Introduction: The age of 18 years is an important milestone for legal matters, and developmental parameters of teeth are often used for estimation of this age. The aim of this study is to assess the efficiency of third molar maturity index (I3M) in establishing age of 18 years in Dakshina Kannada population. Methods: A total of 700 orthopantomograms were retrieved from the archives of the radiology department of Manipal College of Dental Sciences, Mangalore. The length and the width of the open apex of the mandibular left third molar was assessed using Image J software and the Third molar maturity Index (I3M) was calculated and correlated with the age of the individual. Results: Receiver operating characteristic (ROC) curve analysis showed the Area under curve of 0.94 and 0.96 in females and males, respectively, for prediction of age of 18 years. The cut?off of 0.08 predicted the 18?year cut?off with 97% specificity and 90.2% negative predictive value. The percentage of the accuracy was 80.23% if the I3M was <0.08. Conclusion: The efficiency of the cut?off of 0.08 of I3M has been tested in various population including Kosovar, Peruvian, South Indian, Libyan, Montenegro, Croatian, African (Botswana), Albanian, and Serbian. Our study also shows the efficiency of the same in South Indian Dakshina Kannada population.
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Background: Ayurveda is a highly evolved and codified system of life and health science based on its own unique and original fundamental concepts and principles. One of them is the Paradi Gunas (properties). Paradi Gunas (properties) are ten in number and have a wide application aiming at the success of treatment in which, choice of medicine and dietary rules play vital role. For success in the treatment understanding the role and action of a medicine is important, and this can be achieved by the use of Paradi Gunas (properties). Objective: To apply the concept of Paradi Gunas (properties) on Aarogyavardhini Rasa, a ployherbo-mineral medicine during different stages of processing. Data Source: This literary review has used the data source from various online portals as well as books in Ayurveda. Conclusion: The use of Paradi Gunas was studied on the pre-processing, processing and the therapeutic stages of Aarogyavardhini Rasa and its applications were noted. This can be a primary step towards deeper understanding of its role in therapeutics.
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Sacrococcygeal teratomas (SCTs) are the most common extragonadal germ cell tumors, comprised different types of tissues that come from at least two of three germ cell layers. Depending on the tissues that are included, they are divided into mature, immature, and malignant. The incidence of SCT in infants and children is 1 in 35,000–40,000 live births. We are reporting a case of type I SCT. The patient was gravida 3, para 1, and abortion 1, which was diagnosed during antenatal ultrasound examination at 22 weeks of gestation and the termination was done after counseling the parents. A female fetus with a tumor in the sacrococcygeal region, weighing 800 g was delivered. The baby was sent to the department of anatomy. SCTs develop at the base of the coccyx and are thought to be derived from Henson’s node a rounded and elevated area at the cranial end of the primitive streak. This primitive streak consists of totipotent cells, which are able to transform into any type of cells.
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Background & objectives: Bacterial vaginosis (BV) is a Reproduc?ve tract infec?on (RTI) among young sexually ac?ve women with high prevalence. It is associated with complica?ons related to pregnancy and an increased risk of acquiring STDs. This poses a need for cost-effec?ve detec?on of BV in low resource se?ngs. Hence, we propose to study the u?lity of vaginal pH determina?on for the detec?on of BV. Material & Methods: This is a single center, 1 year cross-sec?onal study. Swabs were collected from 250 non-pregnant women a?ending the out-pa?ent department of Obstetrics and Gynecology with vaginal discharge as a predominant symptom with or without backache and abdominal pain. Vaginal pH determina?on, Gram stain, wet mount, Whiff test, and Amsel’s criteria were used for BV detec?on. Results: 250 study par?cipants with vaginal discharge sugges?ve of BV were analyzed. Vaginal pH was significantly higher in women with BV with the mean pH being 6.2. Vaginal pH >4.5 had a sensi?vity of 85% and specificity of 66% to detect BV. The Whiff test had the least sensi?vity. Clue cells and Amsel’s criteria of ? 3 were significant for BV. A combina?on of pH and Whiff test performed be?er had high sensi?vity and specificity. Conclusions: A combina?on of pH determina?on and the Whiff test serves as a low-cost alterna?ve in resource-poor se?ngs for detec?on of BV. Though Clue cells and Amsel’s criteria ? 3 were most sensi?ve and specific, they cannot be used in low resource se?ngs. Vaginal pH alone can be used to detect BV in areas of low prevalence.
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Background: The minimally invasive surgery (MIS) in GBC is being increasingly performed with superior short term results and non-inferior oncological outcomes. Most of the studies on minimally invasive radical cholecystectomy (MIRC) included patients with GBC limited to the gall bladder. Bile duct or adjacent viscera has been resected only in a very few studies. One of the reasons perhaps for not imbibing MIS in advanced GBC is the innate complexity of resection of the involved adjacent organs and need performing a bilioenteric anastomosis. Aim of this study is to assess safety, feasibility and short-term outcomes of locally advanced GBC patients who underwent MIRC with adjacent bile duct or viscera resection. Methods: Retrospective analysis of prospectively maintained data of 11 patients who underwent MIRC with adjacent viscera resection for suspected case of GBC in a single surgical unit between January 2017 to December 2019 at Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, a tertiary referral teaching institute. Results: During the study period 11 patients underwent adjacent viscera resection along with MIRC.Ten patients had Common bile duct (CBD) excision (4 choledochal cyst and 6 direct tumor infiltration), four patients had gastroduodenal resection (3 sleeve duodenectomy and 1 distal gastrectomy with proximal duodenectomy) and three patients had colonic resection (2 sleeve resection and 1 segmental resection). Seven patients had single organ resection (3 CBD and 4 CDC), 2 of them had double organ (CBD & duodenum, duodenum & colon) and 2 patients had triple organ resection (CBD, duodenum and colon). Conclusion: The minimally invasive approach inGBC patients who need extrahepatic adjacent viscera resection was found to be feasible and safe with favourable perioperative and oncological outcomes.Further studies are needed from high-volume centres engaged in minimally invasive hepatobiliary surgery.
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Background: Standard treatment for choledochal cyst (CDC) is excision of cyst with biloenteric reconstruction. Most common methods of reconstruction following CDC excision are Roux en y hepaticojejunostomy (RYHJ) and Hepaticoduodenostomy (HD). Although HD has been employed in paediatric population, its use in adult patients has been limited. Aim: The aim of the study was to analyse our experience of patients who underwent laparoscopic excision of CDC and to compare the short term and long term outcomes following HD versus RYHJ as a method of reconstruction in adults. Methods: This is a retrospective analysis of prospectively collected data of 65 patients who underwent laparoscopic cyst excision from January 2016 to March 2021in a single surgical unit at GB Pant Institute of Post graduate Medical Education and Research, New Delhi. Following CDC excision HD was our preferred as method of biliary reconstruction. Patients with restricted duodenal mobility and thin friable duct underwent RYHJ.Short-term outcomes included operative time,blood loss, length of hospital stay and complications such as anastomotic leakage and post operative bleeding.Long-term outcomes included anastomotic stricture formation and need for redo biliary reconstruction. Results: Total 65 patient underwent laparoscopic CDC excision. Mean age was 31.66 ± 12.77years and male: female ratio was 1:5.4. Type I cyst was the most common (60/65=92.3%) with mean size of 2.59 ±0.78cm. Laparoscopic HD was feasible in 87% (57/65) of patients. RYHJ was done in 8 patients. Outcome in laparoscopic HD vs RYHJ group: Mean blood loss was 54.22±8.9ml vs 92±16 mL, mean operative time was 182±41.6 vs 240±52.2 mL, mean hospital stay was 4±2.1 vs 5±3.2 days. There was no difference in anastomotic leak rate (3 vs 1, p=0.42) or post-operative bleeding rate between the two groups.There was no perioperative mortality. Conclusion: Laparoscopic HD was feasible in most of the adult CDC patients with better short term and comparable long term results.It may be used as the preferred biliary reconstruction method during laparoscopic CDC excision in adults as it is technically easier, requires single anastomosis and also accessible for future endoscopic intervention.
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Background: Silver diamine fluoride (SDF) is one of the effectual cariostatic agents widely used in minimal intervention dentistry. However, the major drawback of SDF is dark staining after its application. Aim: In the present study, the staining of 38% SDF alone and 38% SDF and potassium iodide (KI) was compared after restoration with glass-ionomer cement (GIC) and resin composite using ImageJ software. Methods and Material: Forty extracted carious primary teeth were sorted into four groups. In Group I and II, SDF was applied and restored with GIC and composite restorations, respectively. In Group III and IV, SDF application was followed by KI and restored with GIC and composite restorations, respectively. Images were captured after initial applications on day 1 and day 14 after restoration. The captured images were imported to ImageJ software and mean gray values were calculated. Statistical Analysis: The mean gray values obtained were subjected to statistical analysis using paired t-test and independent sample t-test. There was statistically significant if P < 0.05. Results: Following the application of SDF and RIVA STAR, the baseline mean gray values showed no statistical significance. On day 1, the mean gray values were highest in Group IV (208.30) and lowest in Group I (178.51). Similarly, on day 14, the highest mean gray values were observed in Group IV (208.45) and lowest in Group I (147.6) which were statistically significant. Conclusions: The restorations after SDF application attained dark stain eventually, whereas with the application of SDF followed by KI (RIVA STAR), the restorations showed the least staining.
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Preterm premature rupture of membranes is one of the important causes of premature birth that can result in high perinatal morbidity and mortality along with maternal morbidity. The definition of premature rupture of membranes is rupture of membranes before labour and before 37 weeks of gestation is referred as Preterm PROM. If the membrane rupture is after 37 weeks of gestation, it is Term PROM. The incidence of PPROM ranges from 3 - 10 % of all deliveries and it contributes to 30 - 40 % of all preterm births. METHODSA prospective observational study of clinical analysis of the PPROM in 100 cases of 28 - 37 weeks of gestation which were delivered by caesarean section was conducted from 2018 October to 2019 September in the Department of Obstetrics and Gynaecology of Chalmeda Anand Rao Institute of Medical Sciences, Bommakal, Karimnagar. RESULTSPrevalence of PPROM in the study is 7.8 %. Intra amniotic infection was seen in 32 %. The mean latency period from rupture of membranes to delivery is 3.78 + 2.74 days. 25 % neonates were delivered by caesarean section. There was a total of 12 % perinatal deaths, still births - 4 %, 10 % - early neonatal deaths. CONCLUSIONSIn the current study, the prevalence of PPROM was 7.8 %. Careful antenatal monitoring, detection and prompt treatment of infection is necessary. Strict septic precautions, appropriate therapy, regular antenatal follow up are important factors in the prevention of PPROM. Close antenatal monitoring, identification of risk factors like cervicovaginal infection and their management play an important role in the prevention of PPROM.
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Background: Low birth weight is defined as birth weight below 2500 mg. WHO states prevalence of LBW is 26%. LBW babies are more prone for neonatal morbidity and mortality. 1) To assess various factors like maternal age, height, education, socioeconomic status on the birth weight of the baby. 2) To assess obstetric factors like parity, gestational age, antenatal care, anemia, hypertension on the birth weight of the newborn.Methods: A hospital bound cross sectional study done at the tertiary care centre. Study was done for a period of 2 months from 1st June to 30th July 2019 in Adichunchanagiri Institute of Medical Sciences and Research Hospital a rural medical college in Karnataka. Maternal data were collected and baby weight was recorded soon after birth on weighing scale.Results: There were 65 births during the study period. There were 13 babies weighing less than 2500 gm. Prevalence of LBW was 20%. 43.47% mothers were aged between 18 to 25 years and 7.14% were more than 25 years. 30.4% mother’s height was between 140 to 150 cm and 14.2% were more than 150 cm. Regarding maternal education, 15.3% degree, 24.1% PUC, 15% High school and 33.3% were primary school level. Regarding socioeconomic status 22.2% low, 25% lower middle, 18.7% middle class, 18.7% belonged to upper middle class. Regarding gestational age 50% were <37 weeks, 15.5% between 37-42 weeks, 10% were 42 weeks.73.8% women had normal BP, 21.5% were prehypertensive, 4.6% had PIH.Conclusions: Low birth weight is one of the important factors in infant morbidity and mortality. Maternal health was important factor in delivery of low birth babies. Maternal height, sex of baby, mode of delivery has no role in low birth weight babies.
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Background: The objective of the study was to validate Amit Jain’s staging system for cellulitis in diabetic and non-diabetic lower limbs and to predict the outcomes associated with cellulitis and surgical procedures done in them.Methods: We conducted a prospective study in department of surgery at Raja Rajeswari Medical College and Hospital Bengaluru, India. The study period was from December 2018 to November 2019. Statistical analysis was done using SPSS 22 and R environment ver.3.2.2.Results: A total of 36 patients were included in this study of which 21 were diabetics and were in placed in group A and 15 were non diabetics and placed in group B. 83.3% of the patients were males. 73.3% of non-diabetics had stage 1 cellulitis and 33.3% of diabetics had stage 1 and 2 each. 47.2% of patients underwent debridement and it was significantly common in diabetics (p=0.037) and also it was common in higher stages of cellulitis (p=0.001). 8.3% had amputation in this series. All the major amputations were done in stage 4 cellulitis (p=0.002).Conclusions: In this validation study, it can be seen that cellulitis is common in both diabetics and non-diabetics but it is severe in diabetic patients. Stage 3 was more common in diabetics compared to non-diabetics. Amit Jain’s staging system of cellulitis is a simple, easy, practical, focal classification that guides therapy and predicts amputation.
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Background: Morphometrical evaluation of the larynx has always been interesting for both morphologists andthe physicians. Accurate anatomic knowledge of laryngeal cartilage is essential in diagnostic and therapeuticprocedures in the field of laryngology.Aim: To study morphometric features of thyroid cartilage in adult human cadavers and also to correlate themeasurements of the thyroid cartilage between male and female.Materials and Methods: Thyroid cartilages from 62 cases (Male: 31, Female: 31) of postmortem in the departmentof Forensic medicine, MMC and RI, Mysore were studied. A total of seven parameters were measured on eachthyroid cartilage and the observations were tabulated and compared between both sexes.Results: All parameters of Thyroid cartilage were more in males compared to females except thyroid angle whichwas more in females. The height of right thyroid lamina was equal to the height of left thyroid lamina in bothmales and females. Similarly the Antero- posterior distance of right thyroid lamina was equal to Antero -posterior distance of left thyroid lamina in both sexes.Conclusion: Considerable gender and race related differences in many of the geometric measurements of thethyroid cartilage were observed in the study. These morphological differences have important clinical andsurgical implications. They are critical to the accurate placement of needles and probes in laryngeal electromyography and vocal cord injection, medialization procedures, in performing supraglottic laryngectomy, aswell as precise planning of laryngeal framework surgery.
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Keratins, the epithelial-predominant members of the intermediate filament superfamily, are expressed in a pairwise, tissuespecific and differentiation-dependent manner. There are 28 type I and 26 type II keratins, which share a common structurecomprising a central coiled coil a-helical rod domain flanked by two nonhelical head and tail domains. These domainsharbor sites for major posttranslational modifications like phosphorylation and glycosylation, which govern keratin functionand dynamics. Apart from providing structural support, keratins regulate various signaling machinery involved in cellgrowth, motility, apoptosis etc. However, tissue-specific functions of keratins in relation to cell proliferation and differentiation are still emerging. Altered keratin expression pattern during and after malignant transformation is reported tomodulate different signaling pathways involved in tumor progression in a context-dependent fashion. The current reviewfocuses on the literature related to the role of keratins in the regulation of cell proliferation, differentiation and transformation in different types of epithelia.
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Background: Cranial sutures and their evolution is interesting in the field of cranial growing and shaping. It is adentate suture extending from nasion to bregma. Metopic suture normally closes at 1 – 3 yrs, but is allowed upto 8 yrs. Incidence varies in different races from 1% - 12% .Aim: The present study was done to know the incidence of Metopic suture in south Indian skulls.Materials and Methods: 100 skulls from the Anatomy Dept museum at Shridevi Institute of Medical SciencesTumkur were collected for the present study. The skulls with persistent metopic suture were thoroughly observed.Results: Metopic suture was present in 38%. Complete suture was seen in 3% and incomplete in 35%.Among the3 complete sutures one was linear and continue with sagittal suture measuring 12.3 cm and 2 were H shapedmeasuring 11.0 cm and 12.1 cm. Incomplete sutures were classified depending on the shape U, V, Y and linear.Linear suture was seen in 26 skulls, U shape in 4 skulls, V shape 4 skulls, Y shape 1 skull.Conclusion: The presence of metopic suture is important from a clinical point of view. It must be included indifferential diagnosis of suspected skull fracture particularly frontal bone. It is not a pathological entity butmost certainly should be noted as an incidental finding on an X ray. The suture is best identified in A -P view ofskull
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Aim: To study the effect of various plant growth regulators (PGRs) for induction of somatic embryogenesis and plantlet formation from cotyledon and leaflet explants in S. nigrum (night shade) an important medicinal plant used in treatment of digestive problems and skin infections. Place and Duration of Study: Department of Biotechnology, Kakatiya university, Warangal. Telangana, India, 3 years. Methodology: Cotyledon (0.8 cm2) and leaflet explants (0.8-1.0 cm2) from 3 week and 4 week old were cultured on MS medium supplemented with 30 g/L sucrose along with different concentrations of 0.5 mg/L BAP+NAA (0.5 – 6.0 mg/L) . Results: Maximum percentage of somatic embryogenesis was observed in cotyledon(89%) and leaf (98%) explants on MS medium augmented with 0.5mg/L BAP in combination with 2.0 mg/L NAA whereas the highest number of somatic embryos per explant (86 ± 0.19) was formed in leaflet explant. Conclusion: Somatic embryogenesis was induced from both cotyledon and leaf explants. Since it is threatened and medicinally important species S. nigrum, the present protocol can be used for its conservation and genetic transformation experiments.
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Background: Breastfeeding is the healthiest way to feed a baby. Like mothers love there is no substitute for breast milk. Despite of benefits of breast feeding, the breast feeding incidence and the duration of exclusive breast feeding all over world is not satisfactory. In India though breastfeeding is almost universal, the prevalence of exclusive breastfeeding as per WHO recommendation is not up to the expectations. Over one million infants worldwide die every year because they are not breastfed or because they are given other foods too early. The determination of indicators and variables related to exclusive or overall breastfeeding duration can be a valuable instrument when planning local actions and policies aimed at improving breast feeding rates. Aim: To assess the knowledge, attitude and practices of mothers regarding breast feeding and to determine the impact of lactation counseling to mothers around the time of delivery on breast feeding practices. Material and Methods: Our study was a single center cross sectional questionnaire based study conducted in a Teaching Hospital in Telangana state in India. Duration of study was from October 2016 to September 2018. It was conducted upon 600 (n=600) women i.e. Expectant mothers admitted in antenatal wards and mothers in labour room and postnatal wards of our hospital, who were otherwise healthy. These women were randomly divided in to two groups Group A and Group B. Group A (n=300), Women interviewed after delivery with a preset questionnaire which included 22 questions pertaining to knowledge, attitude and practices of breastfeeding. For Group B (n=300), women brief counseling was given just before delivery in the antenatal wards or in the labour room. Counseling was done by women who were appointed as support staffs under NRHM. These women were given basic training on ideal breastfeeding practices as per Infant and Young Child Feeding Kannaiah B, Radha Mohan M, Snigdha, Sharada. Impact of Lactation Counseling To Mothers on Breast Feeding Practices. IAIM, 2019; 6(2): 13-22. Page 14 (IYCF) guidelines by SNCU pediatricians in our hospital. Mothers in Group B were also interviewed with the same questionnaire by the same interviewer after delivery. The data from the questionnaire of the two groups were analyzed and compared using open EPI INFO statistical methods. Results: Early initiation of breast feeding was observed in 88 % (252-mothers) of Group B compared to 67 % (201-mothers) in Group A. Among the literate women 75% (98-mothers) of Group A and 94% (138-mothers) of Group B women followed early initiation of breast feeding where as in illiterate women early initiation was noticed in 31% (92-mothers) of group A and 41%(114-mothers) of group B mothers. Media played minimal role 16% (48 mothers) of group A and 9% (12 mothers) in group B in encouraging breast feeding. Support from family members & hospital staff had positive influencing on breastfeeding in the groups. 71% (213) of Group A and 89 % (254) of Group B mothers felt breast feeding should be continued for two years and beyond. Conclusion: It revealed that mothers, in virtually all cultures and communities, have considerable knowledge and experience related to all aspects of maternal and child development, and that they have a strong commitment to promoting the well-being of children, their mothers, and families. ‘To have enduring effects, interventions must have an impact on social norms’. In particular, in households in traditional societies around the world, older women or grandmothers play a leading role in decision. They also serve as the primary caregivers of women and children and will continue to play-important role in mother and child health. Thus early initiation of breast feeding, antenatal counseling, educating other family members and support of media etc. will have major role in promoting exclusive breast feeding.
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Wandering or ectopic spleen is a rare condition in which spleen is located outside its normal location. Wandering spleen is an incidental finding with a reported incidence of <0.2%, fewer than 500 cases reported worldwide in literature. It presents as a diagnostic challenge as it can easily mimic a neoplastic mass, an abscess, or an organized hematoma. Ultrasonography and contrast tomography are useful radiological methods in the diagnosis of wandering spleen. We report here autopsy case of a 51-year-old male with wandering spleen in gastric wall diagnosed on histopathology but presented as gastric mass mimicking malignancy. This case highlights the importance of radiology and histopathology in the diagnosis of an ectopic spleen. In the absence of spleen on radiology at a normal site and with a presence of intra-abdominal mass, the clinician should keep in mind ectopic spleen as a differential diagnosis
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Objective : To evaluate the effectiveness of predischarge pulse oximetry as screening for critical congenital heart disease(CCHD) in Term and near term newborns. Methods : This was a prospective case control study conducted in the Neonatal intensive care unit and postnatal wards of a tertiary hospital ,Delhi.The study period was from june 2014 to November 2015,and followed up to 3 months. Inclusion criteria :-Healthy near term (35 to 37 completed weeks of gestation) and term (37 to 42 completed weeks of gestation) neonates .Exclusion criteria :-Neonates with any congenital malformation detected antenatally, Neonates requiring care in the neonatal intensive care unit., Severe IUGR and Maternal intake of drugs apart from the nutritional supplements. The pulse Oximetry Probes were applied to right upper limb (Preductal) and right lower limb (Postductal) in a calm /awake baby for about 3 min for saturations and their difference was recorded. Amean of three readings were taken. Oxygen saturation SPo2 <95% or differential saturation >3%was considered screen positive and sent for echocardiography for confirmation. Statistical analysis : Data was entered in a predesigned proforma in MicrosoftExcel. The data was then analyzed statistically using Stata software version 11(Stata Corp, College Station, TX). Continuous data with normal distribution was analyzed by student t test and non-normally distributed data by Wilcoxon rank sum test (Mann-Whitney). Categorical data was analyzed by chi-square or Fisher exact test. APvalue of <0.05 was taken as significant. Results : Of the 4100 term and near term neonates screened 427(10.4%) babies were screen positive and 3273(89.6%) babies screen negative with pulse oximetry. Total of 42 newborns screen positive for detection of CHD by SPO2 constituted 9.8% (42/427). out of 42 screen positive newborns for SPO2 . Echocardiography examination in these newborns revealed congenital heart disease in 59.5% (25/42). The sensitivity and specificity of SPO2 for detection of CCHD was 80% and 99% respectively ,whereas positive predictive value(PPV) and negative predictive value(NPV)was 9.5% and 100% respectively. Pvaluewas significant (<0.0001) . Conclusion :The technique of pulse oximetry is simple , reliable and an effective method of screening for detection of CCHD .