ABSTRACT
Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). However, no data are available from any Indian population on the association of this variant with NSCLC. Using TaqMan genotyping chemistry, we conducted a case–control study involving 190 NSCLC cases and 400 ethnic, age-matched controls to explore the association of rs10937405 genetic variant with NSCLC in patients from north India. Our data support that the rs10937405 variant is also significantly associated with the NSCLC and is a risk factor in the north Indian populations to develop NSCLC. However, unlike most other studies, the wild-type allele T appears to be the risk allele, as its frequency was significantly higher in the cases than controls (0.439 in cases versus 0.383 in controls. OR=1.95 (1.23–3.09 at 95% CI); P value (adjusted)= 0.004). Genetic association was also observed by applying different genetic models. The present study provides important information of the genetic aetiology of NSCLC and strengthens GWAS findings, highlighting the role of TP63 in lung cancer risk.
ABSTRACT
Multiple myeloma (MM) is a malignancy of plasma cells and the second most common hematologic malignancy (13%); these cells accumulate in bone marrow and overproduce a monoclonal protein. The bone disease develops in 80–90% of patients with MM includes bone pain, pathologic fractures (40%), spinal cord compression (5%), and hypercalcemia. Pathological fractures can occur in extremities, but bilateral involvement is extremely rare. We report a case of 65-year-old male presented with a chief complaint of spontaneous bilateral humerus shaft fractures. On subsequent workup, MM was confirmed. The patient was managed with internal fixation bilaterally and showed favorable union at 1-year follow-up