ABSTRACT
New complexes of Co(II), Ni(II), Cu(II), Cd (II), Pt(II),and Pd(II) with 4-(trifluoro-4-ylidene) hydrazine carbothioamide have been synthesized. All the new compounds were characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, LC-MS. H1NMR, FTIR and electronic spectral studies. Based on the molar conductance measurements in DMF the complexes may be formulated as [Ni(L)2Cl2] and [M(L)2]X2 (where M = Co (II), Cu (II), Cd (II), Pt (II) and Pd(II) and X = Cl - , CH3COO - due to their non electrolytic nature respectively. The antimicrobial activities of the ligand and their complexes have been studied by screening the compounds against the bacteria E. coli and S. aureus and also the fungi Asperillius niger and candida albicans and results have been compared with standard drug streptomycin and fluconazole. The data indicate that the metal complexes have higher antimicrobial activity than the free ligand and the standard drug. The DNA cleavage experiments, performed using gel electrophoresis with the corresponding metal complexes in the presence of H2O2 showed that all the complexes afford a pronounced discernible DNA cleavage evidenced by the disappearance of form I (supercoiled) of DNA and the production of formII (Linear).