ABSTRACT
Objective: Chronicosteomyelitis isthe infectionand inflammation ofthe bone.Inappropriate useof antibiotics and multidrugresistancehas raised themorbidityand mortalityrate in chronic osteomyelitis. This studyaims to determine thebacterial profileand antimicrobial susceptibility patterns ofchronicosteomyelitis with special mention to various resistant mechanisms.Methods: The study is a prospective design.Hundred (100) clinicallydiagnosedcases of chronicosteomyelitis of allagegroupand both sex admitted in a tertiarycarehospital at centralIndia, in oneyearwereincluded. Samples likepus, sinus dischargeorexudates werecollectedasepticallyand sent for microbiologicalinvestigation. Antimicrobial susceptibilityof bacterial isolates tothe commonlyusedantibiotics was doneby using modifiedKirbyBauer discdiffusion method.Results:Theaerobicbacteriological studyof chronic osteomyelitis showedStaphylococcus aureus is being continued to be major etiologicalagent followed byPseudomonas aeruginosa and Staphylococcus epidermidis. Gram-positive isolates weresensitive to linezolid, teicoplanin while gram-negativeisolates weresensitive to colistin, ciprofloxacin in the majority. The diseaseoccurs mostlydueto traumatic injuries commonlyaffectingthe middleagegroup.In present study prevalenceof methicillin-resistant Staphylococci aureusand βLactamaseproducing (ESBL, Amp-C and MBL)gram-negativebacilliis found to beon the higher side.Conclusion: It has been the majorcauseof morbidityfor a longtime. The emergingmultidrug-resistant strain is a major concern forthe treatment.Identification ofcausativeisolates and usinga judicious selection ofantibiotics willhelp theclinician in startingtheempirical treatment accordinglywould limit themultidrug resistancestrains in the hospital as wellas the community