ABSTRACT
Background: Endometrial cancer is one of the commonest cancers in women. Unopposed estrogen stimulation of the uterus is amongst one of the etiologies postulated for this condition. It is generally assumed that women with polycystic ovary syndrome are more likely to develop endometrial carcinoma. Aim: This study hypothesized comparing the ovarian morphology of women diagnosed with endometrial carcinoma and those with benign gynecological conditions. Materials and methods: The present study included a total 64 patients who had been diagnosed with endometrial carcinoma and with 42 age matched control. All biopsy samples were undergone routine histological process with Hematoxylin-Eosin stain to check morphological differentiation. Results: There was found no significant difference in the prevalence of PCOS (using this as a marker of PCOS in the absence of information on biochemistry) in the ovaries of patients diagnosed with endometrial cancer compared to women with benign gynaecology disease. Conclusion: Although our numbers were small, these results challenge the assumption that PCOS is a risk factor for endometrial cancer. Investigation of patient records revealed there was no significant difference in the demographic profile between subjects with endometrial carcinoma or benign gynecological conditions.
ABSTRACT
Background: Preeclampsia is a hypertensive related complication of pregnancy; Parturients with pregnancy induced hypertension may present to the labor and delivery unit with or without a prior diagnosis of preeclampsia and may pose a significant anesthetic challenge. Administration of anesthesia in such cases leads to worse cardiovascular response. Objectives: To determine the efficacy of epidural and spinal anesthesia techniques in preeclamptic parturients. Materials and methods: A total 60 women with severe preeclampsia who required anti-hypertensive therapy and suitable to either spinal or epidural anesthesia were included and were divided in to epidural and spinal groups with equal number of distribution. Results: There were significant differences in SAP at 1 to 15 min (P < 0.0001) and at 16 to 20 min (P < 0.005) and DAP at 1 to 15 min (P < 0.0001) and at 16 to 20 min (P < 0.01) between the 2 groups. There were no significant differences in SAP and DAP at 22 to 30 min between groups. Conclusion: Spinal anesthesia for cesarean delivery in severely preeclamptic patients causes slightly more hypotension than epidural anesthesia during the induction to delivery period. The duration of hypotension, however, was short and there was no difference in neonatal status.
ABSTRACT
Background: Accurate prediction and diagnosis of uterine abnormalities has become a core part of the fertility work-up. A variety of modalities can be used for the diagnosis of uterine abnormalities Transvaginal ultrasonography (TVS) is one among all. Aim: To determine the efficacy of TVS ultrasonography in screening for endometrial disease and studied the concordance of abnormal endometrial thickness, as measured by ultrasonography, with diagnoses based on histopathological examination of endometrial biopsy specimens. Materials and methods: A total 200 Subjects were elected from OPD of ESIC Hospital, Hyderabad. All subjects were undergone to the routine clinical and blood investigation, ultrasound, transvaginal and colour doppler investigations. Results: Study of primary infertility the diagnosis by transvaginal ultrasound and histopathology matched in 82% cases, while in 18% cases there was a disparity among the two modes of investigation. Conclusion: TVS can play an effective role in diagnosis and management of primary infertility, as it has a greater patient compliance with non-invasive technique and without necessitating full bladder. It can replace the EB in the diagnostic work up of female infertility.