ABSTRACT
To evaluate the influence of anthropometric measurements on abnormal gonadotropin secretion in patients with polycystic ovary syndrome [PCOS]. Cross-sectional study. The Institute of Basic Medical Sciences [IBMS], DUHS in collaboration with Gynae/infertility clinics of the Civil Hospital and Lady Dufferin Hospital, Karachi, from October 2010 to February 2011. One hundred and sixty three oligomenorrhic PCOS women of reproductive age [18 - 40 years] fulfilling the revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma included current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI and waisthip ratio. Blood samples for gonadotropin assay were taken randomly on day 6th to 30th of menstrual cycle, in a gel tube. Hormonal assay was performed using chemiluminescent immunoassay. Kruskul Wallis test was used to assess the influence of BMI levels on LH:FSH values. The mean weight was 66.14 +/- 11.02 kg and mean BMI was 27.03 +/- 4.42 kg/m2. There was no significant difference in mean LH/FSH ratio [p=.575] among BMI groups. However, there was a positive correlation between BMI and LH:FSH ratio [p=0.04, r=0.155]. There was high frequency of obesity [69%] in women with PCOS. Although no significant difference was found between mean LH:FSH ratio among different BMI groups levels but significant correlation between BMI levels and LH: FSH suggested that there was positive relation between BMI and LH: FSH
ABSTRACT
To assess the frequency of elevated LH/FSH ratio>l in women with polycystic ovary syndrome among local population. Cross-sectional study. This cross sectional study was carried out at two tertiary care hospitals in Karachi during October 2010 to Feb 2011. A total of 163 PCOS women of reproductive age [18-40years] fulfilling revised Rotterdam 2003 criteria were studied. The data recorded on a prescribed proforma include current age, age at menarche, menstrual irregularities, presence of hirsuitism, acne, infertility, familial nature, blood pressure, BMI, waist to hip ratio. Blood sample for gonadotropin assay were taken in random state on specific dates of menstrual cycle [day 6[th] to day 30[th]] in gel tube. Hormonal assay were performed using chemiluminescent immunoassay. Mean age of presentation of PCOS subjects was 24.88 +/- 5.35 years. Menstrual irregularities [99%] were the commonest presentation followed by acne [88%], hirsuitism [71%] and infertility [62%]. A high frequency [>71%] of elevated LH/FSH >1 ratio was observed among local population. The present study concludes that elevated LH/FSH ratio>l is a characteristic finding of Pakistani population of PCOS [present in = 71% of patients] and with proper sampling dates can be used as diagnostic tool for establishing the diagnosis of PCOS