ABSTRACT
In older to study the interrelationship between laryngeal carcinoma and human papillomavirus (HPV). The distribution and expression of genome types of HPV in laryngeal carcinoma were investigated. HPV DNA of 160 cases of fresh tissue samples with different lesions of the larynx was detected by applying consensus primers and multiple primers of polymerase chain reaction (PCR) . The consensus primers used were able to detect 9 types of HPVs DNAs such as HPV6, 11, 16, 18, 31, 33, 34, 42 and 58. The results turned out to be as follows: The rate of positive cases with HPV infection was 49.3% (35/71) for the group of laryneal carcinoma, 22.7% (5/22) for the group of neck metastatic lymphnode, 11.8% (2/17) for precarcinomous lesions and 6.7% (2/30 ) for the group of vocal cord polypus, 20 case of normal laryngeal tissue adjacent to the carcinoma was HPV DNA negative. The results demonstrated that the occurrence and development of laryngeal carcinoma were closely related to HPV infection.
ABSTRACT
Scanning Electron Microscopic [SEM] observations on the laryngeal surface morphology of the elderly with high incidence of laryngeal cancer [LC] show that it differs from surface morphology of fetus or infant. With age parts of laryngeal macosa undergo squamous metaplasia. This is the first step towards squamous cell cancerization and pathologically accounts for 99 per cent of laryngeal cancer being squamous cell carcinoma, regardless of site of its origin being either squamous epithelium or pseudosrtatified ciliated columnar epithelium