Incidence of gall bladder malignancy in patients with cholelithiasis

A prospective study was carried out in the Department of Surgery, Chandka Teaching Hospital Larkana from January 1997 to December 1998. One hundred cases of cholelithiasis were reviewed for malignancy [80 females and 20 males]. Out of these 10 percent patients were found to have carcinoma of the gall bladder. Their ages ranged from 41 to 69 years, with mean age of 52.2 years. Carcinoma of the gall bladder was found to be more common in the 5th decade of life. Common presenting symptoms were upper abdominal pain [100 percent] nausea and vomiting [80 percent], weight loss [50 percent], jaundice [40 percent] and anorexia [20 percent] Abdominal mass was palpable in two patients. Preoperative diagnosis with the help of ultrasound was possible only in three cases. Histopathologically, all the cases were adenocarcinomas. In majority of the cases, stones were mixed with cholesterol as a predominant component

Gastric teratoma: a case report with review of literature

Gastric Teratoma is a benign tumour that occurs rarely. Following is the report of such a case in a six months old infant who presented with an abdominal mass with multiple abscesses. He was successfully treated by performing partial gastrectomy with complete removal of the tumour

Cancer breast Larkana experience

Retrospective study of 378 cases of CANCER BREAST reported at Larkana Institute of Nuclear Medicine and Radiotherapy [LINAR] during 1985-1992 [8 years] is presented. Averagely about 47.25 cases reported per year. Left breast was involved in 198 cases [52.38%] and right breast in 1 80 cases [47.62%]. Maximum number of cases 233 [58.99%] belonged to age group 31-50 years. There were 359 [94.98%] females and 19 [5.02%] males. Patients belonging to Larkana District, 147 cases [38.88%] topped the list, followed by Khairpur, 55 cases, [14.55%], Sukkur, 52 cases, [13.75%], and Jacobabad 52 cases [13.75%]. Lymphadenopathy was present in 46.29% of cases and metastasis in 34.39% of cases. Surgery was done in 303 cases [80.15%] with simple mastectomy in 182 cases [60.06%] being the commonsest proceedure. 291 [76.98%] patients received chemotherpay, 315 [83.33%] Radiotherapy and 100 [26.45%] hormone therapy. Histopathology was done in 268 cases [70.89%] with infiltrating duct cell carcinoma in 222 cases [82.85%], being the most common lesion. Since the patients present with advanced disease, it is recommended that early reporting should be stressed through media

Lymphoma of breast

A case of lymphoma of breast in a young lady is described, inspite of aggressive treatment consisting of surgery, chemotherapy and radiotherapy, the patient could not survive long

Malignant melanoma of the eyelid in a Pakistan woman

Malignant melanotic tumors occur infrequently in Pakistan, and an eyelid malignant melanoma is even rare. During a prospective study of the eye tumors in Sindh, we saw a 65-yea-old woman who had a malignant melanoma of the right lower eyelid, the first such published documentation from Pakistan. The tumor had metastasized to preauricular lymph nodes, the enlargement of which had been apparent to the patient for nearly six months. The management included full thickness eyelid and preauricular lymph node excision followed by local irradiation. No recurrence occurred during the first six postoperative months, after which the patient unfortunately was lost to follow-up. [Pakistan Journal of Ophthalmology 9:41-42, April, 1993.]

Higher incidence of eyelid squamous cell carcinoma in comparison to basal cell carcinoma

According to this study, the incidence of eyelid squamous cell carcinoma [45%] is nearly twice the incidence of basal cell carcinoma [25%] in the upper Sindh and the surrounding areas of Baluchistan, Pakistan. Also, squamous cell carcinoma occurred twice as frequently in the lower eyelid [six cases] than in the upper eyelid [three cases]. Both of these findings are contrary to the established views of the Western authors and publications. Nonetheless, more research is needed in all parts of the country to confirm this most interesting discovery of our study. Out of a total of 20 histopathologically studied eyelid tumors collected from the Department of Ophthalmology and the Department of Pathology, Chandka Medical College, Larkana, nine [45%] were squamous cell carcinomas, 5 [25%] basal cell carcinomas, one [5%] sebaceous adenocarcinoma, two [10%] neurofibromas, one [5%] compound nevus, and one [5%] tricho-epithelioma. One lesion [5%] was a chronic tuberculous granuloma. The racial, genetic, socioeconomic, and environmental factors may be responsible for this reverse trend in the relative incidence of squamous and basal cell carcinomas of the eyelid. All of the patients in this study were from the poor socioeconomic group