ABSTRACT
Osteoporosis can be defined as a systemic skeletal disease characterized by low bone mass and micro architectural decline of bone tissue. Serum amyloid A [SAA] is a family of protein that increases up to 1,000-fold in blood during inflammation. In this study, we aimed to study the relationship between SAA1 gene polymorphism [rs12218] and lipid profile and osteoporosis. The study was performed on the female students of Taibah University in Al Medina, KSA during June 2014 to April 2015. According to BMD; osteoporosis group [138 students] and control group [128 students]. All groups were subjected to; BMI, BMD, calcium, phosphorus, creatinine, lipid profile and SAA. Polymerase chain reaction and Real Time were done to determine the distribution of allele and genotype frequency of SAA [rs12218] C/T polymorphism. This study shows that the TT genotype of rs12218 was more frequent in osteoporosis group than control group [P<0.001]. Also, TT genotype and T allel was found to be associated with plasma total cholesterol, TG, LDLc, HDLc, Tscore, Zscore and SAA1 level in osteoporosis group [l*k].000, P=0.05, and P=0.000, P-0.000, P-0.01, P=0.02, P=0.000 respectively]. The logistic regression analysis with and without lipid disorders in the osteoporosis group also show that the TT genotype of rs12218 still differed significantly between these two groups [P=0.001,OR=1.814, 95% Cl: 0.719-4.577]. The results of this study shows a significant association between TT genotype of rs12218 and both lipid level and osteoporosis in Saudi female population
ABSTRACT
In postmenopausal women, ovarian stromal hyperplasia and endometrial cancer are often identified concurrently. The aim of the present study was to verify the association of ovarian volume with histologic findings and sex hormones levels in women with postmenopausal bleeding and thickened endometrium. Prospective observational study conducted in a teaching hospital between March 2008 and February 2010. Ninety women with postmenopausal bleeding and thickened endometrium [>/=5 mm] were enrolled. They underwent vaginal sonography for ovarian volume measurement. Blood samples were collected for sex steroid hormones assay. In addition, endometrial sampling was done for definitive histologic diagnosis. According to histologic results, 18 cases [20%] had endometrial adenocarcinoma, 24 cases [26.7%] had endometrial hyperplasia with or without atypia and 48 cases [53.3%] had benign histologic findings. Large ovaries were significantly associated with higher body mass index [BMI>/=30] [P=.002] and endometrial adenocarcinoma [P < .001]. After adjustment for age and BMI, increased ovarian volume in adenocarcinoma was associated with high serum level of estradiol [P < .001], serum total testosterone [P=.04] and serum free testosterone [P < .01] compared with other histologic findings. Large ovaries among women with postmenopausal bleeding and thick endometrium were associated with elevated serum sex steroid hormones and represent a marker of risk for endometrial adenocarcinoma.
ABSTRACT
To examine the serum retinol levels of wheezing children, and to investigate the relation as an biochemical indicator of vitamin A status in wheezing children between serum levels of retinol and severity of wheezing. A prospective cohort study including 400 wheezing Saudi children aged 3-36 months, who were treated in the pediatrics ward of Ohoud Public Hospital in Al-Madinah, Kingdom of Saudi Arabia between January 2009 and August 2010. Patients were subdivided according to the course of wheeze into 93 patients with persistent wheeze, and 307 patients with acute wheeze. Severity of wheeze was graded mild, moderate, and severe. Among the persistent wheezing patients 9.7% had deficient, and 20.4% had marginal serum vitamin A concentration, while in the acute wheezing patients, 1.6% had deficient, and 8.1% had marginal serum vitamin A concentrations. Results revealed that the prevalence of deficient and marginal vitamin A concentration is higher in the persistent than in the acute wheezing group [p<0.05]. Serum vitamin A was related to wheezing severity. Deficient serum vitamin A was found only in severe wheezing groups. Wheezing Saudi infants had prevalent deficiency and marginal deficiency of vitamin A. Serum vitamin A concentrations were related to the wheezing severity and course