ABSTRACT
Objective :To explore mobilizing effect of spironolactone by spironolactone on peripheral blood endothelial progenitor cells (EPCs) in patients with acute myocardial infarction ,and its impact on cardiac function .Methods :A total of 136 patients with acute ST elevation myocardial infarction treated in our department were randomly and e‐qually divided into routine treatment group and spironolactone group (received spironolactone 20mg／time ,once／d based on routine treatment group ) ,both groups were treated for three months .Peripheral blood EPCs level before and 7d after treatment ,cardiac function indexes before and three months after treatment were compared between two groups.Results :After 7d treatment ,peripheral blood EPCs level in spironolactone group was significantly high‐er than that of routine treatment group [ (1. 12 ± 0. 26)% vs.(0.53 ± 0. 14)%, P＝0. 001].Compared with routine treatment group after three‐month treatment ,there was significant rise in LVEF [ (51. 47 ± 8.23)% vs.(56. 52 ± 8.84)%] ,and significant reductions in LVESd [(34. 52 ± 3. 16) mm vs.(32.90 ± 2. 68) mm] and LVEDd [(57. 82 ± 8.13) mm vs.(53. 65 ± 7.22) mm] in spironolactone group , P＜0. 01 all.There was no significant difference in incidence rate of adverse reactions between two groups , P＝0. 595. Conclusion :Spironolactone can significantly in‐crease peripheral blood EPCs level and cardiac function ,and inhibit myocardial remodeling in AMI patients .