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Objective To assess the myocardial microcirculation of patients with hypertension using intravoxel incoherent motion (IVIM) diffusion-weighted imaging, and to analyze the differences compared with normal volunteers. Methods Thirty normal volunteers and 18 hypertensive patients, who underwent cardiac magnetic resonance cine and IVIM scans in our hospital from May 2015 to Sep. 2018, were enrolled. The IVIM scan was performed on middle view of left ventricular short-axis with 8 b values (20, 50, 80, 100, 120, 200, 300 and 500 s/mm2). The structural and functional parameters were measured on left ventricular short-axis, and the IVIM parameters (fast apparent diffusion coefficient [ADCfast], slow apparent diffusion coefficient, fraction of ADCfast) were measured using biexponential model. The differences of all parameters were analyzed between the normal volunteers and hypertensive patients. Results The left ventricular ejection fraction, cardiac output and myocardial mass of the hypertensive patients were higher than those of the normal volunteers ([68.39±7.51]% vs [63.20±5.22]%, [6.84±2.03] L vs [5.41±1.08] L, and [122.54±33.63] g vs [85.97±25.42] g), and the differences were significant (t=-2.75, -2.64 and -4.15; all P0.05). The ADCfast of the hypertensive patients was significantly lower than that of the normal volunteers (0.12 [0.03-0.17] mm2/s vs 0.14 [0.10-0.21] mm2/s, Z=-2.83, P<0.01). Conclusion The application of IVIM can contribute to evaluating myocardial microcirculation of the hypertensive patients.
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Objective: To investigate the efficacy of surgical resection of giant adult-onset cystic lymphangioma in the axilla and chest wall. Methods: Various clinical parameters were analyzed in three patients with axilla and chest wall giant cystic lymphangioma in past eight years in our department. They all accepted CT scan or MRI to assess lesions anatomic relations pre-operation. We resected their polycystic ingredients with S-shaped spindle incision, ligated the stump of lymphatic vessels, removed excess skin and reconstructed armpit. Results: All patients had nice shape, no deformity, no obvious scar formation and no recurrence post-operation. The follow-up period is 8, 4, 2 year respectively. Conclusion: The causes of adult-onset cystic lymphangiomas in the axilla and chest wall are still not clear, partially related to the pregnancy. Surgical resection using the S-shaped spindle incision could help to hide the incision, protect the axillary vessels and brachial plexus, resect tumor completely. Ligating the proximal end of lymph duct on the subclavian and the top of axilla can reduce the recurrence. MR is a good diagnostic method to observe its border.
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<p><b>OBJECTIVE</b>To explore the factors associated with early diagnosis of gastric cancer.</p><p><b>METHODS</b>Clinical data were retrospectively analyzed for 250 patients with early-stage gastric cancer (EGC) from 2005 to 2008, during which the concept of intra-epithelial neoplasia (IN) was adopted in our department.</p><p><b>RESULTS</b>On preoperative endoscopic biopsy with pathological exam, there were 15 cases suspicious for cancer, 90 with high-grade IN (HGIN), and 15 gastric cancer. Postoperative pathological exam of the surgical specimen showed infiltrating early-stage cancer in 224 patients, of which 5 (2.2%) were type I (all were Tsm), 190 (84.8%) were type II including Tm in 82 and Tsm in 108 patients, 29 were type III (5 Tm and 24 Tsm). Twenty-six patients had non-infiltrating lesions (Tis). There were 184 (73.6%) well-differentiated tumors, including 26 Tis, 58 Tm, and 100 Tsm. Lymphatic metastasis was identified in 21 patients, of which 2 (2.3%) were Tm (all were poorly-differentiated) and 19 (13.9%) were Tsm. Lymphadenopathy was present in 15 (7.9%) cases in type II, and in 6 (20.7%) in type III. Of the 90 cases with a preoperative diagnosis of HGIN, 24 were found to be Tis, 29 were Tm, and 37 were Tsm on postoperative pathological assessment.</p><p><b>CONCLUSIONS</b>Well-differentiation is the main histological type in EGC. The adoption of the concept of IN is associated with improved detection of EGC, which warrants further investigation.</p>
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Female , Humans , Male , Middle Aged , Carcinoma in Situ , Pathology , Lymphatic Metastasis , Pathology , Neoplasm Staging , Retrospective Studies , Stomach Neoplasms , PathologyABSTRACT
<p><b>OBJECTIVE</b>To study the loss of heterozygosity (LOH) on chromosome 3p in breast cancers and precancerous lesion.</p><p><b>METHODS</b>LOH at 11 microsatellite loci was detected in 41 cases of breast cancers and 12 cases of precancerous lesion by polymerase chain reaction and silver stain. The expressions of ER, PR, FHIT and hMLH1 were detected in breast cancer by immunohistochemistry.</p><p><b>RESULTS</b>LOH on 3p was detected in 97% of breast cancers. D3S1295, D3S1029 and D3S1038 located at 3p14, 3p21-p22 and 3p25 were identified as the loci with most frequent LOH (53.1%, 43.6% and 52.5%). LOH of D3S1038 and expression of hMLH1 protein correlated with several clinicopathological features. LOH of D3S1295 had significant negative correlation with the expression of FHIT. In breast precancerous lesions, LOH on 3p was detected in 41.7% lesions. D3S1295 and D3S1029 were also identified as the most frequent LOH locus (27.3% and 16.7%). The smallest common LOH region seems likely lie between 3p14 and 3p25.</p><p><b>CONCLUSIONS</b>The smallest LOH region indicates the existence of breast tumor related genes and some of them affect gene expression.</p>