Comparison of long-term clinical outcomes between transvaginal mesh and pelvic floor reconstruction with native tissue repair in the treatment of advanced pelvic organ prolapse / 中华妇产科杂志

Objective:To study the long-term clinical effect of transvaginal mesh (TVM) and pelvic floor reconstruction with native tissue repair (NTR) in the treatment of advanced pelvic organ prolapse (POP).Methods:Totally 207 patients with advanced POP who were treated in Hunan Provincial Maternal and Child Health Care Hospital from Jan. 2016 to Sep. 2019 were enrolled. The patient′s pelvic organ prolapse quantification were all at degree Ⅲ or above, and they all complained for different degree of symptoms. They were divided into two groups according to the different surgical methods, TVM group and NTR group. In TVM group, the mesh was implanted through the vagina for pelvic floor reconstruction, while in NTR group, the traditional transvaginal hysterectomy combined with uterosacral ligament suspension and anterior and posterior wall repair, as well as perineal body repair were performed. The median follow-up time was 60 months, during the follow up time, 164 cases (79.2%, 164/207) had completed follow-up, including 76 cases in TVM group and 88 cases in NTR group. The perioperative data and complication rates of the two groups were compared, and the subjective and objective outcomes of the two groups at 1, 3 and 5 years were observed, respectively. The objective efficacy was evaluated by three composite criteria, namely: (1) the distance from the farthest end of the prolapse of the anterior and posterior wall of the vagina to the hymen is ≤0 cm, and the descending distance of the top is ≤1/2 of the total length of the vagina; (2) determine the disappearance of relevant POP symptoms according to “Do you often see or feel vaginal mass prolapse？”; (3) no further operation or pessary treatment was performed due to prolapse. If the above three criteria were met at the same time, the operation is successful; otherwise, it was recurrence. The subjective efficacy was evaluated by the pelvic floor distress inventory-short form 20 (PFDI-20) and pelvic floor impact questionnaire-short form 7 (PFIQ-7).Results:The median follow-up time of the two groups was 60 months (range: 41-82 months). Five years after the operation, the subjective and objective cure rates of TVM group were 89.5% (68/76) and 94.7% (72/76), respectively. The subjective and objective cure rates in NTR group were 80.7% (71/88) and 85.2% (75/88), respectively. There were significant differences in the subjective and objective cure rates between the two groups ( χ2=9.869, P=0.002; χ2=3.969, P=0.046). The recurrence rate of TVM group was 5.3% (4/76), and that of NTR group was 14.8% (13/88). There was a significant difference between the two groups ( P=0.046). The postoperative PFDI-20 and PFIQ-7 scores of the two groups were significantly lower than those before surgery, and there were significant differences of the two groups before and after surgery (all P<0.05). Postoperative mesh exposure in TVM group was 1.3% (1/76). Conclusions:The long-term outcomes between the two groups show that the subjective and objective outcomes of pelvic floor reconstruction in TVM group are significantly higher than those in NTR group, and the recurrence rate is significantly lower than that in NTR group. TVM has certain advantages in the treatment of advanced POP.

Mechanism of regulating immune dysfunction of sepsis based on network pharmacology and experimental verification / 中国药理学通报

Aim To verify the role of Shengjiang Powder in sepsis and explore its molecular mechanism. Methods The targets of drug active ingredients and disease-related targets were searched by TCMSP, Disgenet and other databases, and the intersection of the two was selected. DAVID database was used to carry out enrichment analysis of GO and KEGG pathways for intersection targets, and molecular docking was performed between drug active ingredients and core genes of key pathways. Mouse model of sepsis was constructed by cecal ligation puncture (CLP). Spleen tissue and serum of mice were collected. The percentage of T cell subsets in spleen was detected by flow cytometry, and IL-6 and IL-10 levels in serum were detected by ELISA. Results A total of 25 active ingredients, 238 targets of active ingredients, 2797 disease-related targets, 90 genes of intersection between active ingredients and disease-related targets, potential targets were AKT, JUN, EGFR, MMP9, etc. GO enrichment analysis showed 1021 items, including 942 biological processes, 23 cell compositions and 55 molecular functions. KEGG pathway analysis found that the intersection genes were mainly enriched in THE PD-1/PD-L1 signaling pathway, HIF-1 signaling pathway, TNF signaling pathway and inflammatory mediators signaling pathway, indicating that the therapeutic effect may be related to these pathways. The molecular docking results showed that quercetin, kamanol, emodin and other core compounds could be well combined with key genes. Flow cytometry results showed that after seven days of CLP, the proportion of CD4 T cells in spleen decreased, the proportion of CD4 PD-1 T cells increased, the release of IL-6 decreased, the content of IL-10 increased, and the mice were immunosuppressed. The percentage of CD4 T cells in spleen increased, the number of CD4 PD-1 T cells decreased, the release of IL-6 was enhanced, the content of IL-10 decreased, and the immunosuppression was improved. Conclusions It is proved that Shengjiang Powder can increase the release of pro-inflammatory cytokine IL-6, increase the ratio of CD4 T/CD8 T cells, and decrease the expression of anti-inflammatory cytokine IL-10 in the late stage of sepsis, so as to improve immune suppression in the late stage of sepsis and improve the survival rate of mice.

Analysis of adherence and determinants of sublingual immunotherapy in patients with Artemisia pollen-induced allergic rhinitis / 临床耳鼻咽喉头颈外科杂志

Objective:To monitor adherence to specific sublingual immunotherapy （SLIT） in patients with seasonal allergic rhinitis（AR）, analyse factors influencing adherence, and provide research support to effectively improve adherence. Methods:Patients with AR who underwent Artemisia pollen SLIT at the Department of Otolaryngology-Head and Neck Surgery, First Hospital of Shanxi Medical University from May 2021 to April 2022 were retrospectively followed up by telephone to investigate the current status of treatment, count the causes of shedding, and extract relevant information from their medical record data for analysis. Results:Of the 112 patients surveyed, 34 discontinued treatment（30.3%）; patients who experienced adverse reactions and SLIT patients who had been on treatment for more than 6 months showed relatively good adherence（P<0.05）. The main reasons for discontinuation in patients who dropped out were: asymptomatic discomfort during the non-pollen phase and therefore discontinuation of treatment or feeling that treatment was ineffective 9 cases（26.5%）, forced discontinuation due to vaccination or pregnancy, or epidemics 6 cases（17.6%）. Conclusion:Long-term adherence of patients to Artemisia pollen SLIT still needs to be brought to the attention of healthcare professionals, especially in the early stages of treatment when good patient education and good channels of trust and communication between doctors and patients need to be established.

Preparation technology of platelet-rich-plasma lysate combined with hyaluronic acid microneedles and wound healing effect / 中国输血杂志

【Objective】 To investigate the application prospect of platelet-rich plasma lysate (PL) microneedles in the treatment of wound healing by optimizing the preparation process and evaluating the activity of platelet growth factor. 【Methods】 Firstly, hyaluronic acid (HA) was used as needle matrix material, and the concentration of HA was preliminarily determined by investigating the fluidity of HA solution, shape of needle, pressure change performance and puncture performance.Combined with the results of HA dissolution in PL, mechanical properties of PL microneedles and skin puncture, the preparation process of platelet-rich plasma lysis microneedles (PLMN) was optimized to investigate the growth factor activity of PLMN and evaluate the effect of PLMN on wound healing in rats. 【Results】 When the concentration of HA was 30 mg/mL, the solution had good fluidity.The HA microneedles could pierce three layers of sealing film, with the puncture rate at 70%, and the solution had good mechanical properties.When HA was dissolved in PL at a concentration of 30 mg/mL at 4℃, the solution had no crystallization and was with good fluidity.The prepared PLMN showed good needle shape and no bending under HD microscope and scanning electron microscope.In vitro transdermal simulation results showed that PLMN could penetrate 4 layers of sealing membrane, and the puncture rate of the first three layers was more than 85%.In vivo lysis experiment showed that PLMNs could be completely dissolved within 10 min after being inserted into the body.Forty minutes later, the micropores left after the insertion of the microneedle were almost closed, without redness, swelling, erythema and other adverse reactions.In vitro and in vivo transdermal experiments showed that clear blue holes were visible after PLMNs penetrated the skin stain, indicating that the microneedles could pierce the skin barrier.Growth factor detection results showed that the content of platelet-derived growth factor (PDGF-BB) and transforming growth factor (TGFβ1) in platelet lysate were (17.67±1.23) ng/mL and (105.95±2.16) ng/mL, respectively.After PLMNs were prepared and stored at room temperature for 1 week, the content of PDGF-BB(ng/mL) and TGFβ1(ng/mL) were 15.48±2.12 and 56.26±1.53, respectively.Compared with PL(vs 17.67±1.23 and 105.95±2.16), the content of PDGF-BB and TGFβ1 decreased, but still maintained the activity of growth factors.The results of wound healing experiment in rats showed that the wound healing rate (%) of PLMN group on the third day was significantly different from that of the control group(52.51±6.15 vs 33.31±3.60, P<0.05). 【Conclusion】 The PLMN prepared in this experiment has good mechanical properties and can successfully pierce the skin cuticle.It can also maintain the activity of growth factors, and has a good effect on wound healing in rats, which provides a new idea for minimally invasive treatment in the field of tissue repair.

Effects of sulforaphane on anxiety and fear memory in AD mice and its oxidative stress mechanism / 中华行为医学与脑科学杂志

Objective:To explore the effects of sulforaphane (SFN), an activator of Nrf2, on anxiety and fear memory in Alzheimer's disease(AD) model mice and mechanism.Methods:The AD mice and wild type (WT) mice with the same background were randomly divided into four groups ( n=12 for each group): wild type + normal saline group (WT+ NS), wild type + sulforaphane (WT+ SFN), AD model + normal saline group (AD+ NS) and AD model + sulforaphane group (AD+ SFN). SFN was dissolved in normal saline (0.9% NaCl) and prepared solution with concentration of 1 g/L.According to body weight, mice in WT+ SFN group and AD+ SFN group were intraperitoneally injected with SFN (10 mg/kg), and mice in WT+ NS group and AD+ NS group were intraperitoneally injected with the same volume of normal saline once a day for 30 days.The open field test was used to detect the autonomous exploration ability and anxious behavior of mice.The elevated cross maze was used to detect the anxiety of mice.Conditional fear test was used to test the fear memory behavior of mice.Finally, the expression of superoxide dismutase(SOD) and malondialdehyde(MDA) in the hippocampus and cerebral cortex were detected by ELISA.Two-way ANOVA analysis was performed using GraphPad Prism 8.0.2 software. Results:In the open field test, the percentage of time in central region in AD+ SFN group ((9.99+ 0.37)%) was higher than that of AD+ NS group ((8.47+ 0.42)%) ( q=3.842, P<0.05). In the elevated cross maze, the percentage of time in open arm of AD+ SFN group ((26.2±1.6)%) was higher than that in AD+ NS group ((15.8±1.0)%) ( q=7.452, P<0.01). In the conditional fear test, all the mice of the four groups developed the fear memory, but AD+ SFN group showed higher freezing time ratio ((64.5±3.8)%) than AD+ NS group ((51.0±4.3)%)( q=5.266, P<0.01) in the testing stage.After SFN intervention, the important indicator of oxidative stress, the expression levels of SOD in hippocampus ( q=6.370, P<0.01) and cortex ( q=7.858, P<0.01) of AD mice increased, while the level of MDA in hippocampus ( q=5.146, P<0.05) and cortex ( q=5.833, P<0.01) decreased. Conclusion:SFN may inhibit oxidative stress through Nrf2 pathway, thereby improving anxiety and fear memory in AD mice.

Analysis of published articles supported by Clinical Nursing Fund in 12 core nursing journals from 2015 to 2018 / 中华医学科研管理杂志

Objective:To understand the status quo and problems of clinical nursing fund paper publication in China from 2015 to 2018.Methods:The clinical nursing fund papers published in 12 core nursing journals and published by Chinese Authors in WOS database were analyzed by using bibliometrics methodology. Information analyzed including year distribution, number of authors, regional distribution, the number of institutions, research nature, research type, statistical application, specialty distribution and research content.Results:From 2015 to 2018, the proportion of clinical nursing fund papers was increasing, the proportion of funded papers in Chinese and WOS was 44.06% and 51.46% respectively, the main funding sources of each project came from provinces or direct-controlled municipalities level(42.02% in Chinese and 33.06% in WOS). Chinese fund papers were mainly co-authored by four people (20.18%) and mostly from the same institution (67.83%), the fund papers collected by WOS were mainly co-authored by six people (21.14%) and mainly produced by two institutions (40.65%). Clinical trials (26.64%) were the main research types of Chinese funded papers, and statistical inference (73.15%) was the main application of statistical methods. Jiangsu (14.58%) produced the most Chinese fund papers, and the first authors of the fund papers collected by WOS mostly came from Taiwan (43.90%); the main research topics were oncology nursing (16.65% in Chinese and 22.49% in WOS) and disease and symptom nursing (23.57% in Chinese and 23.04% in WOS).Conclusions:The number of papers on clinical nursing fund was increasing year by year, the application of statistics is basically stable, the sources of fund funding were increasingly diversified, and the trend of scientific research cooperation was increasing. Economically developed areas were the main force of scientific research output. The focus of clinical nursing research was oncology nursing and disease and symptom nursing.

Concern and influencing factors of freshman knowledge in Sichuan university / 中国学校卫生

Objective@#To understand the concern of freshmen with different characteristics on sexual knowledge in Sichuan province and to provide evidence for comprenensive sex education in colleges.@*Methods@#A survey was conducted among 2 532 freshmen from 13 universities in Sichuan Province in September 2018. Attention to specific sexual knowledge among students with different characteristics was analyzed.@*Results@#Sexual knowledge that the freshmen concerned included partner communication (39.25%~55.10%), STD and AIDS (37.78%~44.85%) and gender equality (33.33%~43.34%). Logistic regression results showed that male students payed more attention to partner communication(OR=0.77,95%CI=0.65-0.91), masturbation (OR=0.36，95%CI=0.27-0.47) and sexual minorities (OR=0.61,95%CI=0.41-0.90), while female students payed more attention to gender equality (OR=1.31,95%CI=1.10-1.57), sexual harassment and violence (OR=1.65,95%CI=1.37-1.98). Rural students pay. more attention to partner communication (OR=0.79,95%CI=0.65-0.94), while urban students pay. more attention to masturbation (OR=1.50,95%CI=1.08-2.08), sexual harassment and sexual violence (OR=1.30,95%CI=1.07-1.58). Students who had sex were more concerned about contraception and unwanted pregnancy than those who had not (OR=0.53,95%CI=0.39-0.72). Sexual minority students were more concerned about topic of sexual minorities than heterosexual students (OR=3.50,95%CI=2.30-5.33).@*Conclusion@#College freshmen with different characteristics varied in their concern on sexual knowledge, which is related to their needs. It is suggested that schools set up comprehensive education courses according to the needs of students, the content of sex education knowledge can be focused, and carry out comprehensive and targeted sex education.

Research Progress on the Molecular Mechanisms of Toxicology of Ethanol-Aconitine Induced Arrhythmia / 法医学杂志

Aconitum is one of the most widely used Chinese herbal medicines, and aconitine is the major toxic component in it. Aconitine can induce a variety of arrhythmias, resulting in death. Acute ethanol consumption causes arrhythmia as well. Poisoning cases caused by aconitum medicinal liquor are frequently encountered in the practice of forensic medicine. The molecular mechanisms of myocardial toxicity of these two drugs have much in common, and both of them affect the sodium channel, calcium channel and potassium channel of myocardial cell membrane and so on. This paper analyzes and discusses the possible co-effects of ethanol-aconitine on cardiomyocyte channel proteins, by reviewing researches on the mechanism of cardiotoxicity of ethanol and aconitine in recent years, in order to provide ideas and references for the research on the molecular mechanism of arrhythmia caused by combined poisoning.

Analysis of clinical nursing zero cited funded papers published in 12 core nursing journals from 2012 to 2014 / 中华医学科研管理杂志

Objective To explore the zero cited fund papers in clinical nursing in China,in order to provide evidence for improving the academic quality and cite rate of nursing papers.Methods Bibliometric statistical analysis was used to summarize zero cited papers published in 12 nursing core journals from 2012 to 2014.Indicators collected including the distribution of time,journals,funding number,funding sources,research methods,research design type,statistics method,number of cooperative people,nature of the authors' organizations,as well as the conditions of cited papers and the distribution of themes.Results The overall zero cited rate of clinical nursing zero cited fund papers was 74.64％.Affiliated hospital of colleges account for a large proportion of 42.53％,and the zero cited rate in the national disease research center and the affiliated hospital of army colleges was the highest (100.00％ and 80.52％).The oncology nursing,disease and symptoms care proportion was 13.94％ and 23.10％.The output of TCM care and rehabilitation care fund paper accounted only 3 and 8 respectively,and none was cited.The zero cited rates of social support,care coordination,treatment and care attitude and evidence-based research were 96.3％,94.12％,91.67％,90.32％.Strengthened their awareness of research applications,managers focused on research papers in the number of outputs at the same time and paid attention to the paper quality,and promoted scientific research into nursing,and promoted the development of nursing discipline.Conclusions The current paper-citing situation in clinical nursing was not optimistic,nursing research personnel should correct the attitude of scientific research,strengthen their own sense of scientific achievement applications.The management personnel should pay more attention to the paper quality,and promote nursing research outcome transformation,promote the development of nursing discipline.

Application of Mixed-effect Model in PMI Estimation by Vitreous Humor / 法医学杂志

Objective To test the changes of the potassium(K+)and magnesium(Mg2+)concentrations in vitreous humor of rabbits along with postmortem interval(PMI)under different temperatures, and explore the feasibility of PMI estimation using mixed-effect model. Methods After sacrifice, rabbit carcasses were preserved at 5℃, 15℃, 25℃ and 35℃, and 80-100μL of vitreous humor was collected by the double-eye alternating micro-sampling method at every 12 h. The concentrations of K+and Mg2+in vitreous humor were measured by a biochemical-immune analyser. The mixed-effect model was used to perform analy-sis and fitting, and established the equations for PMI estimation. The data detected from the samples that were stoned at 10℃, 20℃ and 30℃ with 20, 40 and 65 h were used to validate the equations of PMI estimation. Results The concentrations of K+and Mg2+[f(x,y)] in vitreous humor of rabbits under different temperature increased along with PMI(x). The relative equations of K+and Mg2+concentration with PMI and temperature under 5℃~35℃ were fK+(x,y)=3.413 0+0.309 2 x+0.337 6 y+0.010 83 xy-0.002 47 x2 (P<0.000 1), and fMg2+(x,y)=0.745 6+0.006 432 x+0.033 8 y(P<0.000 1), respectively. It was proved that the time of deviation for PMI estimation by K+and Mg2+was in 10 h when PMI was between 0 to 40 h, and the time of deviation was in 21 h when PMI was between 40 to 65 h. Conclusion In the ambient temperature range of 5℃-35℃, the mixed-effect model based on temperature and vitreous humor sub-stance concentrations can provide a new method for the practical application of vitreous humor chemi-cals for PMI estimation.

Peptidome Analysis of Transudative Pleural Effusion by Ultra-filtration Coupled with Nano-Liquid Chromatography-Tandem Mass Spectrometry / 分析化学

The peptides,proteins and other biological molecules in transudative pleural effusion correlate directly or indirectly with specific physiological and pathological state,reflecting the information regarding the lungs or other parts of the body.In the present study,the peptide fraction in transudative pleural effusion was isolated by uhrafiltration.After desalted and enriched by C18 tips,the peptide mixture was analyzed by nano LC-MS/MS.The results showed that 314 peptides,which were originated from 52 proteins,in pleural transudate were identified.More than half of the peptides were derived from fibrinogen.Many peptides were characterized as displaying ladder sequences.In addition,a large number of proline oxidation modifications were detected in the peptides derived from collagen and fibrinogen.Gene ontology enrichment analysis showed that the most of the proteins extracellular properties of pleural transudate polypeptide components were protein with exocytosis.The study provided a rapid and efficient separation and analysis methods for lung disease markers related peptide compounds in pleural fluid leakage.Also this research provided a rapid and effective method for screening peptide biomarkers related to lung diseases from transudative pleural effusion.

Effect of different hysterectomy on ovarian hemodynamics / 中国基层医药

Objective To investigate the effect of laparoscopic hysterectomy and open hysterectomy on ovarian hemodynamics.Methods Selected 132 patients who underwent hysterectomy,among them,76 cases (laparoscopic group)underwent laparoscopic hysterectomy,56 cases(open group)underwent open hysterectomy.The preoperative and postoperative ovarian artery hemodynamic parameters,T cell subsets and serum hormone index of the two groups were observed.Results In the observation group and the control group postoperative 48h,the pulsatility index(PI), resistance index (RI),systolic blood flow velocity maximum (Vmax)and diastolic stage blood velocity minimum (Vmin)decreased(all P <0.05),which of postoperative 2 weeks increased(all P <0.05).The RI,Vmax and PI in the observation group postoperative 48h and 2 weeks were (1.17 ±0.16)and (1.30 ±0.14),(0.66 ±0.11)and (0.70 ±0.06),(11.80 ±3.10)m/s and (12.17 ±3.26)m/s,(3.01 ±0.19)m/s and (2.98 ±0.20)m/s,which were all higher than those in the control group(t =-10.637 and -7.609,-5.880 and -2.583,-5.084 and -3.271,-13.660 and -4.826,all P <0.05).The CD +4 and CD +3 T cells levels of the observation group and control group postoperation were increased(all P <0.05),and the CD +8 T cells levels were decreased(all P <0.05).The CD +4 and CD +3 T cells levels of the observation group postoperative 48h and 2 weeks were (43.50 ±3.50)% and (47.20 ±3.16)%, (73.50 ±6.17)% and (80.06 ±9.20)%,which were higher than those in the control group(t =-6.859 and -5.599,-5.515 and -4.853,all P <0.05),while the CD +8 T cells were (37.52 ±5.10)% and (34.10 ±3.20)%,which were lower than those in the control group(t =3.007 and 3.214,all P <0.05 ).The estradiol(E2 )levels of the observation group and control group were significantly decreased(all P <0.05),follicle stimulating hormone(FSH) levels were significantly increased(all P <0.05).The E2 levels of the observation group postoperative 1 month and 3 months were significantly lower than those of the control group(all P <0.05),FSH levels were significantly higher than those of the control group (P <0.05).Conclusion The effect of laparoscopic hysterectomy on ovarian hemodynamics, ovarian function and immune function is small,and it is worth to be popularized in clinical application.

Analysis of citations of literatures of nursing staff from quotations of five nursing periodicals from year 2010 to 2012 / 中华医学科研管理杂志

Objective To investigate the habits that literatures using by nursing staffs during 2010 to 2012 in China.Methods The publication from Chinese Journal of Nursing, Nursing Research, Chinese Journal of Practical Nursing, Journal of Nurses Training and Journal of Nursing Science from year of 2010 to 2012 were statistically analyzed using literature metrology method.The statistics results were compared with data from 2007 to 2009.Results In past 3 years, the quantity,quantity of papers with citations, average number of citations, citations of theses with citations published in-mentioned above five periodicals increased year by year.In 2010 to 2012, the average number of citations and citations rate of papers also improved compared with 2007 to 2009.The type citation is mainly from Journals,and the language was mainly in Chinese.Conclusions In the past 3 years, the nursing staff's literature utilization was improved.However, in the situation of using references with foreign language, nursing staff was poor comparing with medical personnel.On the scientific research ability of nursing personnel training should be strengthened,and the application of new technology and new theory in domestic and international should be strengthened as well..

Open Lip Schizencephaly with Agenesis of Corpus Callosum: A Rare Embryological Defect In Combination.

A five week old newborne presented with recurrent abnormal movements . The child was borne of normal parents with non consangious marriage . There was no history of any ailment of mother during pregnancy and she was not on any drugs. The baby was borne by normal delivery and The CT Scan of the head showed Schizencephaly with Agenesis of Corpus Callosumwith gyralmalformation. Therewere no associated anomalies. Facial features were well developed and the muscle tone and power of the child was normal. The blood investigations were normal as was metabolic profile.

The status of patentable invention by nursing professionals in recent years / 中华医学科研管理杂志

Objective To understand the current status of nursing patentable invention.Methods The patent literature published in nursing journals from 2010 to 2013 were analyzed to obtain related information.Results The results show an increasing trend in the number of patents of patient care;patent inventor distributed in 25 provinces and municipalities, mainly level 3 hospitals (89.86％), nurses with undergraduate degree (76.76％) and senior nurses (50.28％).The patents focused on the life care appliances (such as improved disease clothing, toilet equipments, the cleaning utensils, cutlery improvement, etc.), infusion, injection therapy appliance (such as infusion sets, syringes, dosing auxiliary device, infusion fixtures, etc.), airway care paraphernalia, washing, and drainage equipments, etc.Of all the nursing patents, utility model patents accounted for majority, and only 3 of them were invention patents.Conclusions The trend of nursing patentable invention show good momentum, but the quality needs to be improved.The innovation training for nurses is necessary;and it is also important to increase support to establish an innovation environment.

Liver lacerations in abdominal trauma – Management based on anatomical Knowledge: Case series.

The Liver is commonly injured following penetrating trauma and the second most commonly injured organ following blunt trauma. Due to the soft consistency of the liver parenchyma the injuries are often minor and can be easily managed. The article pinepointd the various anatomical and surgical characteristics and how they relate to liver injuries and trauma management. We reported here two cases of abdominal trauma where both the patients had liver injuries in the form of laceration and bleeding within the substance of liver. The first case was of a young patient who had a high velocity road traffic accident and was brought to the casualty in a state of shock. The Second pattient had a fall from bike and fell on the road by his side.

Morphology of Brachialis Muscle: Variations and Clinical Significance.

Background: Though rare but variations of brachialis muscle insertion have been reported. Material and Methods: The study was conducted on 115 upper limbs over a period of 4 years. The dissection of arm and forearm was done carefully to preserve all minute details ,observing the morphology of insertion pattern and nerve supply. Observation: Out of 115 specimens, 2 specimens showed insertion of brachialis into bicipital aponeuroses. Accessory slips were seen in 4 specimens which are mixed with main fibers at insertion point. Rarest of all was insertion of an accessory brachialis muscle on radial tuberosity in 2 specimens. The muscle originated from lateral border of shaft of humerus and shared a few fibers with main Brachialis muscle. The muscle was inserted into radius just below the radial tuberosity. Conclusion: The identification of an inter-nervous plane may allow for improvement in the current anterior and anterolateral surgical approaches to the humerus. This could be one of a possible etiology of Radial tunnel syndrome.

MORPHOLOGICAL AND MORPHOMETRIC STUDY OF JUGULAR FORAMEN IN SOUTH INDIAN POPULATION.

Background: The jugular foramen, the bony opening on the base of skull, is an opening through which pass the ninth, tenth, and eleventh cranial nerves, two dural sinuses, and the meningeal branches of the occipital and ascending pharyngeal arteries. The increasing use of modern diagnostic procedures and new surgical approaches has created a need for much more detailed anatomical studies and explanations. This article reveals some additional features. Material and Methods: 324 jugular foramina of skulls of persons of unknown age and gender were examined. The morphological characteristics of all the investigated jugular foramina were described, measured, and compared, taking into consideration their side. Results: Jugular foramina were studied for a review of its morphology, morphometry and its comparison with previous studies. Different shapes and sizes of jugular foramen were seen. Laterality was also noticed, compartmentation was also observed which was found to be statistically significant. Conclusions: A detailed examination of the jugular foramen anatomy was performed. The main types of jugular foramina and the frequencies of bipartite or tripartite division were established. Several dimensions of the parts of the jugular foramen were measured. Some new data could provide important information about the anatomy of the jugular foramen for reliable surgical interventions in this area.

Bibliometrics analysis of nurse drug prescription related research in foreign countries / 中华医学科研管理杂志

Objective To know about the current status and developing trends of the nurse drug prescription of foreign countries.In order to Provide reference for China.Methods All literatures related to nurse drug prescription in 1981-2011,were searched in the PubMed database.then use Microsoft Excel to sort and analyze the database.Including the database's Annual distribution,SCI publication status,Journal distribution and main content.Results From 1981 t0 2011,515 articles related to nurse drug prescription were collected totally.The number of publications and the collaboration status increased in recent years approximately.The main content include status in quo,laws and regulations,Policy support as well as education and training and so on.Conclusion The foreign countries have implemented nurse drug prescription for a long time,laying emphasis on the Policy,management,education and practice every aspect of nurse drug prescription,and its development degree Is increasing year by year.So that they can Provide a good reference for China.

Research on motives and influence factors of scientific research of nursing staff / 中华医学科研管理杂志

Objective To analyse the research motives and its influencing factors of nursing staff.Methods 1000 authors who wrote for “Nursing Research” were chosen with a random code sampling method and were surveyed with a questionnaire,which inquired about their research motivation and self-rated research ability scale.Results Nursing research motives include to summarise clinical experience66.2％ (524/793),to get promotion 55.4％ (420/793),to contribute to nursing profession 37.2％ (295/793),to report research achievements 35.6％ (282/793),and to meet the requirements of the institution17.5％ (139/793).Research motives were statistically different in terms of age,work expirence,educational background,professional title,attitude,research training,research ability,and work institution (P =0.013,0.037,0.048,0.002,0.024,0.008,0.005,0.009,0.004,P＜0.05).Conclusions To stimulate the enthusiasm for research in nursing staff,administrators need to pay great attention to higher education for nurses,enhance their research training,provide research platform,and to improve the incentive system.