ABSTRACT
Effects of n-butanol extract of Atractylodes japonica Koidz. ex Kitam. (NEG)on gastric ulcer were stud ied in 6 experimental models. The results showed that NEG inhibited the formation of gastric ulcers induced by acetic acid,plylorus-ligation or indomethacine,but it lacks efficacy in gastric ulcers induced by stress or re serpin. NEG at a dose of 0. 18g/kg significantly increased the PGE2 content in gastric juice (P
ABSTRACT
Dicarboxyethyl Germanium Sesquioxide ( DEG ) is a organic germanium compound of artificial synthesis. It could inhibite gastric lesions in pylorus-tightened rats, increased the levels of PGE2 and markedly reduced pepsin activity and free acid of gastric juice. DEG also inhibited formation of indomethacine, pentagastrin and alcohol induced ulcer. It could accelerate the healing of acetic acid ulcer, but couldn't against acute stress and reserpin produced gastric ulcer. The secretory reaction of chief cell of DEG groups were reduced markedly than control. To sum up, the prineiple mechanism of anti-gastric ulcer of DEG may be by raising the levels of PGE2 in gastric juice and inhibiting pepsinia and promoting synthesis of protein.