Current status of the research on psychosocial factors in patients with nonalcoholic fatty liver disease / 临床肝胆病杂志

Unhealthy dietary habits and a sedentary lifestyle have led to a significant increase in the prevalence rate of non-alcoholic fatty liver disease (NAFLD) in children, adolescents, and adults. In recent years, the biological-psychological-social medical pattern has attracted more and more attention, and internal psychosocial factors have become an important influencing factor for disease progression, treatment, and prognosis. Studies have shown that patients with NAFLD may experience psychosocial disorders, and this article summarizes the common psychosocial problems of these patients.

Safety and efficacy of percutaneous transluminal coronary angioplasty in octogenarian Chinese / 中华老年医学杂志

Objective　To evaluate the safety and efficiency of percutaneous coronary interventions(PCI) in octogenarian Chinese with coronary artery disease.　Methods　A total of 43 patients aged over 80 years old underwent 45 such procedures at Queen Mary Hospital from October 1994 to May 1998. There were 27 male and 16 female 〔 mean age (82.3±2.5), range (80-89)〕. 55.8% of these patients had multi-vessel lesions. A total of 48 lesions in 43 patients was treated 〔25 LAD(52.1%), 11 LCX(22.9%) , 11 RCA(22.9%), 1 LM (2.1%)〕. 　Results　Thirty-seven (86.1%) patients were successfully performed PCI. Sixteen of them deployed stenting. Among the 6 lesions which failed to cross, 5 of lesions were LAD, 3 of them were total occlusion. The success rate and complication during the procedure were not significant difference compared with the control in 237 patients ＜80 years of age. At 18 months follow up, 78.5% of these patients was free or much improved of chest pain. The restenosis rate was 36.0% confirmed by coronary angiogram performed in 25 patients. 　Conclusions　In octogenarians with coronary artery disease PCI was a safe and effective procedure with a high successful rate, low acceptable complication rate and a favorable immediate and long term outcomes.

Construction of the Reporter Vector Controlled by Two Tandem Copies of Estrogen Response Elements in Yeast / 环境与健康杂志

Objective To establish the recombinant yeast estrogen system(RYES),a reporter vector controlled by estro-gen response elements(ERE)in yeast was constructed.Methods pLacZi-1RER was obtained first by inserting an ERE which was synthesized artificially into the yeast reporter vector pLacZi which had already been lined by SalI and the terminal dephos-phorized by CIAP.Then,pLacZi-zERE.was obtained by inserting another ERE into the XhoI site nearby the ERE in pLacZi-1ERE.Results Sequence analysis indicated that the yeast reporter vector controlled by two tandem copies of ERE was con-structed successfully.Conclusion The yeast reporter vector controlled by ERE,pLacZi-2ERE,was constructed successfully,which was the very important groundwork for further establishment of the recombinant yeast estrogen system(RYES).

Coronary angioplasty in patients younger than 40 years of age:early- and long-term outcomes / 中国介入心脏病学杂志

Objective To evaluate the effect of PTCA in patients younger than 40 years of age. Methods Patients aged 40 years or less who underwent PTCA were recruited. Clinical and angiographic data were reviewed. Results A total of 82 patients underwent such procedures. Successful PTCA were performed in 80 patients (97.56%), 93 lesions were treated (97.89%), resulting in an improvement in diameter stenosis from 84.5%?11.8% to 4.1%?1.2%. One patient (1.22%) required bypass surgery without death and Q-wave myocardial infarction. During 42.1?6.8 months′ follow-up, 3 patients died (non-cardial cause in two cases), 3 sustained a myocardial infaraction, and 1 required bypass surgery. 87.8% of patients were free of angina. The target vessel revascularisation rate (TVR) was 12.19%. Angiographic follow up were performed in 70 patients (8.4?5.2 months). The total restenosis rate was 31.43%, 13.16% in stent group. Conclusion Coronary angioplasty has a high immediate success rate and good long-term result when performed in young patients who can be treated safely and effectively with coronary interventions.

Study on Endocrine Disruptor Chemicals Causing Malformed Frogs / 环境与健康杂志

Objective To study endocrine disruptor chemicals causing malformed frogs in an irrigation canal in T city and a pool in CH city. Methods Water samples collected from an irrigation canal in T city and a pool in CH city where malformed frogs were found were concentrated through H103 resin. The concentrated samples were purified and derivated. The endocrine disruptor chemicals in the derivatives were determined by GC/MS and the estrogenic activities in concentrated water samples were assessed by the recombinant yeast estrogen system (RYES). Results Endocrine disruptor chemicals bisphenol_A (5.6?10-3～1.52 ?g/L) and nonylphenol (0.46～0.58 ?g/L) were found in the concentrated water samples of the irrigation canal in T city and the pool in CH city. RYES showed that the estrogenic activities were positive and this result accorded with the data given by GC/MS. Conclusion The results indicated that the cause resulted in malformation of frogs in the irrigation canal in T city and the pool in CH city might be related to endocrine disruptor chemicals.