ABSTRACT
Objective To explore the failure factors of the immunization of hepatitis B vaccine,in order to provide evidence for adult hepatitis B vaccine immunization.Methods Random seleced the targets by examinations from susceptible population whose age were ≥18 years old,that immunized with 10?g Recombinant hepatitis B vaccine(YDV)three doses followng schedule of 0、1、6 months,then condcted a case-control study to the failure.Results Failure rate of adult administered with 10?g HepB immunity was 12.99%.Among the failures,smoking rate,obesity rate,family history hepatitis B virus infection rate and micro virus infection rate were higher than the control group.There was obvious statistic difference.Conclusion The adult failure factor of hepatitis B vaccine immunity was associated with smoking,obesity,hepatitis B viras infection,family history and micro virus infection.