ABSTRACT
Objective To study the efficacy and toxicity of S-1 combined with oxaliplatin in the treatment of advanced gastric cancer in elder patients. Method Total of 65 elder patients with advanced gastric cancer proved pathologically in 1 st hospital of Nanchang were divided into 2 groups across according to the admission date. 33 cases in the observation group received the S-1 combined with oxaliplatin regimen while 32 cases in the control group received the FOLFOX 4 regimen. Efficacy was evaluated at least 3 cycles. Results The overall response rate and disease control rate between observation group and control group had no obvious differences. The last followed up was September 2013, 54 patients were dead. The median FPS of observation group and control group were 6.1 months and 5.7 months respectively, and the median OS time of observation group and control group were 10.1 months and 9.5 months respectively. The differences between two groups had no statistical significance. The rate of level III~IV adverse digestive reaction was higher in control group than that in the observation group. And there were 2 cases had deep vein catheter related infection in control group. The life quality score were increased in both observation group and control group, and there were obvious differences between two groups. Conclusion S-1 capsules combined with oxaliplatin regimen had same effective rate compared to FOLFOX 4 regimen.And adverse digestive system reaction in S-1 capsules combined with oxaliplatin regimen was less than FOLFOX 4 regimen. Nevertheless, it conveniently to oral method, and could reduce the rate of deep vein catheter related infection.
ABSTRACT
Objective To investigate the prognosis effect of different methods for blocking hepatic blood volume in patients with liver cancer .Methods The clinical data of 105 cases with different methods (whole liver hepatic pedide block concluded 38 cases , semi-block 32 cases ,regiosnal block 35 cases) for blocking hepatic blood volume with liver cancer were analyzed .Results The bloc-king blood loss ,intraoperative blood transfusion ,liver blood blocking and hospitalization time of regional block group were less than those of the whole liver hepatic pedicle block group and semi-block group(P 0 .05) ,but the rate of rea blocked complete remission was significantly higher than that of the other two groups(P<0 .05) .Conclusion The application of regional blood flow in patients with primary liver cancer timely blocking technology can minimize liver tissue hypoxia and ischemia time ,effectively control the liver bleeding cut .