ABSTRACT
A 42-year-old woman with systemic lupus erythematosus (SLE) has had wide-spread erythemas with some purpuric patches on her trunk and upper extremities during exacerbation of her disease. Biopsy findings from erythematous lesions and purpuric areas revealed the pathology of lupus erythematosus and leukocytoclastic vasculitis (LCV) with immune deposits, respectively. A feature of wide-spread symmetrical erythemas with foci of LCV occurring in this patient is considered to be an unusual presentation.
Subject(s)
Adult , Female , Humans , Biopsy , Erythema , Glycogen Storage Disease Type VI , Lupus Erythematosus, Systemic , Pathology , Upper Extremity , VasculitisABSTRACT
BACKGROUND: Packs are viscous preparations that produce a film over the skin surface, thus preventing the evaporation of water and increasing the skin temperature. Because of this occlusive effect, packs can be used as the vehicle to which active pharmacologic agents produce a therapeutic effect. OBJECTIVE: This study aimed to explore the feasibility of pack formulation as a vehicle by comparing percutaneous absorption with ointment formulation. METHODS: After 0.5, 1, 2 and 6 hours of topical applications of 0.05% clobetasol 17-propionate ointment and pack on each forearm of 9 young, healthy male subjects, the amounts of the drug in tape-stripped stratum corneum were assessed using high performance liquid chromatography(HPLC). RESULTS: There was no significant difference with regard to the amount of the drug in tape-stripped stratum corneum between ointment and pack formulations of 0.05% clobetasol 17-propionate. CONCLUSION: Pack formulations delivered similar amount of drugs to the skin compared to ointment formulations, suggesting peel-off type pack can be used as a new vehicle of topical corticosteroids.
Subject(s)
Humans , Male , Adrenal Cortex Hormones , Clobetasol , Forearm , Skin , Skin Absorption , Skin TemperatureABSTRACT
Synthetic progesterones have been used to treat menstrual disorders and to prevent habitual or threatened abortion. Recently, they are increasingly used as a part of assisted reproductive technique(ART) for the infertility related to the luteal insufficiency. Cutaneous reactions related to progesterone are rare and only isolated cases of autoimmune progesterone dermatitis have been described. We report, here in, a case of drug-induced progesterone dermatitis which was proved by positive skin test to intradermal progesterone.
Subject(s)
Female , Pregnancy , Abortion, Threatened , Dermatitis , Infertility , Progesterone , Skin TestsABSTRACT
Papular acantholytic dermatosis localized to the anogenital area is clinically characterized by discrete and grouped papules confined to the anogenital area. Histologically, it shows suprabasal acantholysis resembling that observed in familial benign chronic pemphigus or Darier's disease. However, lack of family history and characteristic skin lesions at other body sites help to distinguish it from those conditions. We describe a 53-year-old woman with unusual asymptomatic, grouped papular lesions on the left perianal area, resembling lichen planus, clinically and familial benign chronic pemphigus, histologically. We think the findings of our patient may represent a distinct acantholytic eruption that should be distinguished from other generalized blistering acantholytic dyskeratotic disorders that may also involve the anogenital area.
Subject(s)
Female , Humans , Middle Aged , Acantholysis , Blister , Darier Disease , Lichen Planus , Pemphigus, Benign Familial , Skin , Skin DiseasesABSTRACT
Hypertrophic discoid erythema is a clinical variant of chronic cutaneous lupus erythematosus (CCLE) found most often in association with the more classical lesions of discoid erythemas. We report two cases of CCLE with hypertrophic discoid erythemas occurred on the arms; a rare form of cutaneous lesion of CCLE.