ABSTRACT
Modern medical Science has offered many surgical procedures like open and closed haemorrhoidectomy, anal dilatation, Sphincterotomy etc for haemorrhoides and fissure in ano. These operative procedures are associated with unavoidable sequel of symptoms like Pain, Discharge and Inflammation etc. Role of analgesia is vital in the treatment of post-operative pain. The mode of analgesia depends on degree or level of pain which is a subjective criteria. Analgesics routinely used are NSAIDs, opioids and corticosteroids. Side effects includes like Gastritis, Gastrointestinal bleeding etc. Hence, Analgesia has to be supplemented with antacids or H2 Receptor Agonists. Here, quest for knowledge for an alternative treatment to analgesics starts. According to Sushrutacharya, these diseases like Arsha and Parikartika are termed as Chhedya, i.e., treatable by surgery and he has indicated Yashtimadhu Ghrita in Shastranipataja Vedana. Methodology- In present study, total 100 postoperative patients of haemorrhoids and fissure in ano, randomly allocated into two groups (50 in each group). In Group A (n = 50), Yashtimadhu Ghrita Gudapurana was done every day after sitz bath for 5 days. In Group B (n = 50), local application of lignocaine jelly every day after sitz bath for 5 days. Result- Yashtimadhu Ghrita as a local application is clinically as effective as lignocaine jelly in the management of post operative pain in patients of hemorrhoids and fissures in ano. Conclusion- it was concluded that Yashtimadhu Ghrita is helpful in the management of pain in the post operative patient of haemorrhoids and fissure in ano
ABSTRACT
The aim of present investigation was to develop and optimize sustained release interpenetrating network (IPN) beads of Delonix regia seed polysaccharide (DRG) and sodium alginate using response surface methodology. Diclofenac sodium (DS) was chosen as model drug. A central composite design was used to study and optimize the effect of independent variables (A: sodium alginate:DRG ratio and B: calcium chloride concentration) on drug encapsulation efficiency (DEE, %) and drug release in 8h (R8h, %). Total thirteen batches of DRG-alginate IPN beads were prepared by ionotropic gelation method using calcium chloride as a cross-linking agent. The DEE (%) of the beads was found in the range 32.79-56.54%. Swelling of beads was high in phosphate buffer (pH 6.8) whereas, less in 0.1 N HCl (pH 1.2). The beads exhibited sustained release of DS for 8h (65.6±0.98 - 99.9±1.87%) and followed Higuchi model demonstrating non-fickian diffusion mechanism. The observed responses of the optimized batch were similar to the predicted values determined by Design Expert (V.7.0, Stat-Ease Inc, USA) software. The optimized DRG-alginate IPN beads may show good encapsulation of water soluble drugs followed by their sustained release for 8h which might be advantageous in terms of advanced patient compliance with reduced dosing interval.