Anti-Hypolipidemic and Anti- Oxidative Effects of Hydroalcoholic Extract of Origanum majorana on the Hepatosteatosis Induced with High-Fat Diet in Rats

@#Introduction: The aim of the current study is to evaluate the antihyperlipidemic and antioxidative effects of hydro-alcoholic extract of marjoram (HAEM) in rats fed with a high-fat diet (HFD). Methods: In the experimental study, the rats were randomly divided into four groups of five rats in each and fed with high-fat diet for 12 weeks as follows: One group (normal diet group) was fed with a standard diet, one group was fed with HFD, and two groups were fed with HFD and orally fed with 150 and 450 mg/kg/day HAEM. The serum samples and liver tissues were used for measuring the biochemical and oxidative parameters and histopathological studies. HFD induced hepatosteatosis in rats as evidenced by the altered liver enzymes activity, serum lipid profile and oxidative status. Results: Serum lipid profile (triglyceride, cholesterol and low-density lipoprotein) in rats fed with HFD + HAEM (150 and 450 mg/kg/day) was significantly decreased. Furthermore, the evaluation of oxidative stress showed a reduction of the malondialdehyde (MDA) level and an increase in ferric-reducing anti-oxidant power. Meanwhile, liver enzyme activities declined in response to HAEM. Conclusion: Using the HAEM could be a future therapeutic agent in treating hepatosteatosis and reducing oxidative damages of HFD in the liver.

Uterocutaneous fistula following cesarean section: successful management of a case

A uterocutaneous fistula is a rare clinical presentation that occurs following Cesarean section and other pelvic operations. There are only a few reports discussing the treatments. We describe a patient with successful surgical management and review the literature. A 25-year-old woman referred to our department 13 months after her first Cesarean section. She had a history of an abdominal mass and collection 2 months after surgery and some fistula opening with discharge from her previous incision. She had a previous surgical operation and antibiotic therapy without complete response. We performed fistulography to evaluate the tracts. In the operation - she had fistula tracts, one of which was between the uterus and skin. We debrided the necrotic tissue in the uterus, excised the fistula tracts, and drained the uterine cavity. At 8 months' postoperative follow-up, she had no recurrence. A uterocutaneous fistula is a rare condition with many causes and needs proper investigation and timely medical and surgical management

report of a rare gastric cancer case: leptomeningeal carcinomatosis

Leptomeningeal carcinomatosis [LMC] from gastrointestinal cancer would be rare. A 56-years old man with complaint of dyspepsia and histopathologic examination of the biopsy specimens has shown: adenocarcinoma. At the end of adjuvant chemo radiation therapy, the patient has affected by headache and mild confusion. In cerebrospinal fluid [CSF] cytology, a plenty of malignant cells have seen and unfortunately after a short time for about 4 days after ICU admission, the patient has died. This could be due to heavy burden of disease in central nervous system

[ frequency of metabolic syndrome among female patients admitted in psyciatry ward]

In recent years the metabolic syndrome has been highly common among psychiatric patients. Since many factors including genetic factors contribute to the prevalence of this syndrome, it seems necessary to look for metabolic syndrome among Iranian psychiatric patients. This cross-sectional study was performed on 130 female patients admitted to psychiatric ward of Mashhad 22 Bahman hospital since March 2009 until December 2009 to find whether they had metabolic syndrome. Questionnaires were completed for patients. Pregnant women and those who had had a delivery during the last 6 months were excluded. Data were analyzed through statistical tests such as t-test and chi square and SPSS software 17. P-value less than 0.05 was regarded as meaningful result. In this study the prevalence of metabolic syndrome was, according to criteria of NCEP [ATP III], 39.8%, which is deemed as significantly more than expectable range for healthy Iranian population. Older age, higher waist circumference, BMI and weight, persistence of diabetes mellitus and hypertension, low educational level and marriage status were proven to be associated with increased risk of metabolic syndrome [p-value <0.05]. There were no meaningful relation between metabolic syndrome, duration of administration and type of drugs, and mental disorder. [p-value>0.05]. In the present study, the prevalence of metabolic syndrome was examined. And it was proved that the rate of the prevalence of metabolic syndrome is more than what is typically found in similar studies among Iranian psychiatric population. No relationship was detected between metabolic syndrome and any specific drug, however, more extensive studies are suggested