ABSTRACT
Glioblastoma (GBM) is a clinically common type of glioma with a very poor prognosis and complex drug resistance mechanisms, high mortality, short survival time; invasiveness and recurrence are the main obstacles to treatment. Ferroptosis is an iron-dependent regulated cell death associated with massive lipid peroxidation that is related with the development and treatment response of various types of tumors. Cancer cells rely on their strong antioxidant capacity to avoid ferroptosis, therefore, exploring ferroptosis may be an effective strategy to prevent tumor proliferation and invasion. This article mainly reviews the mechanism of ferroptosis in GBM, as well as the research status and progress of ferroptosis as a potential therapeutic target.
ABSTRACT
Glioma is a common tumor in the central nervous system. Because the natural immunosuppression of tumor microenvironment is conducive to tumor growth, transformation and migration, the traditional treatment has little effect and is difficult to make a breakthrough. Glioma-associated microglia and macrophage (GAM), an important part of brain tumor microenvironment, plays a more and more key role in tumor progression and regulation of anti-tumor immune response. This article reviews the latest progress of the source, recruitment, polarization and the role in development of gliomas as well as potential therapeutic targets of gliomas.
ABSTRACT
Objective:To investigate the clinical efficacy of electroacupuncture therapy for critical ill patients with acute gastrointestinal injury (AGI).Methods:77 patients were randomly allocated to the treatment group (38 cases) and control group(39 cases).The control group received conventional medical treatment.In the treatment group,electroacupuncture therapy combined with conventional medical treatment was adopted.Treatment was given for seven days.The clinical therapeutic effects were evaluated using the quantity of enteral nutrition (EN) and abdominal cavity pressure changes in 1,3,5,7 days.After the treatment,the percentage of patients with early enteral nutrition (EEN),total enteral nutrition (TEN),parenteral nutrition (PN) supplementedas and the length of ICU stay were also observed.Results:The amount of daily EN in treatment group was significantly higher than that in control group(P ＜ 0.05) and the abdominal cavity pressure was significantly lower in the treatment group (P ＜ 0.05).After treatment,the proportion of EEN and TEN of the treatment group were both higher than control group (P ＜ 0.05) and the percentage of combined EN and PN therapy in the treatment group decreased significantly (P ＜ 0.05).Meanwhile,the mechanical ventilation period and the length of ICU stay in the treatment group were shortened (P ＜ 0.05).Conclusion:Electroacupuncture therapy can effectively improve the intestinal function and have remarkable therapeutic effect in treating critical illpatients with AGI.
ABSTRACT
Objective To retrospective analysis of the clinical effect and complications of the semi-laminectomy approach on the treatment of intra-spinal tumor.To summarize the endoscopic treatment experience of intra-spinal tumor.Methods To retrospective analysis of the clinical data of 24 cases with intra-spinal tumor in Shanxi Provincial People's Hospital from January 2008 to September 2015.The diagnosis of the intra-spinal tumor was confirmed by preoperative MRI examination.Intraoperative application of endoscopic surgery in the resection of tumor.Longterm followed up of patient was implemented and observe the efficacy and complications after surgery.Results Postoperative symptoms of all patients have different degrees of improvement,the degrees of sensory disorder was reduce,the limb muscle strength was increased and alleviate the damages of nerve electrophysiology.No serious complications were found after operation.Of the 24 patients,17 cases were total resection of the tumor and 7 cases were subtoal resection of the tumor.Tethered cord release was operated in patients with tethered spinal cord.Conclusions Endoscopic resection assisted semi-laminectomy approach of intra-spinal tumor has slight damage to the surround structures and the impact to the anatomy of the spine was small.Endoscopic assisted semi-laminectomy approach may have siginficant clinical effect on intra-spinal tumor,and have good security.
ABSTRACT
Objective To explore the methods and techniques of the treatment for epidermoid cyst with endoscope assisted keyhole approach microneurosurgery Methods Sixteen patients with epidermoid cyst were treated with endoscope assisted keyhole approach microneurosurgery Different keyhole approaches were selected according to the position of the tumors With microneurosurgery,larger part of tumor was resected,then under neuroendoscope remains of tumors was found out and removed Result After the tumor were removed with microneurosurgery,the remains of tumors in 13 cases (81 25%) were still found under endoscope,and were resected with endoscope;the remains of tumors in 3 cases were not found Total excision of tumor was achieved in 14 patients (87 5%);Two patients subtotal excision Fifteen cases (93 75%) with clinical symptom had an improvement or recovery 2 weeks operation One case occurred nor bacterial meningitis and recovery 2 weeks after treatment Hydrocephelar and second intracranial hematoma were not found in all patients Following up was carried out for 10 patients after 3 12 months Nine patients got a good result One patient with trigeminal neuralgia Conclusion Endoscope assisted keyhole approach microneurosurgery can increase the total resection rate for epidermoid cyst,reduce the trauma of operation and reaction after operation [Key words] Epidermoid cyst; Intracranial; Neuroendoscope; Keyhole; Microneurosurgery
ABSTRACT
Objective To study the microsurgical excision of large and giant pituitary adenomas via transeyebrow supraorbital keyhole approach and discuss the advantages of this approach Methods Forty four patients were treated with microneurosurgery via transeyebrow supraorbital keyhole approach Transverse incision was made about 5 cm,include external two third of eyebrow The skull window was about 3 cm in diameter The operative space was between subdual and epiarachnoid Under the microscope,border of tumor and its capsule could be found and dissected step by step Tumor was removed piece by piece and could be removed totally The follow up survey after 6 month, includes MRI examination,endocrine changes,visual power and visual field Result Total excision of pituitary adenomas was achieved in 40 patients;2 patients subtotal excision,and large part was removed in another 2 patients There was no mortality in this group The clinical symptoms were improved in all patients Conclusion The transeyebrow supraorbital keyhole technique is a minimally invasive technique and can be used in excision of large and giant pituitary adenomas,it can reduce the operative injury and morbidity