ABSTRACT
Traumatic brain injury (TBI) and Cannabis has been implicated as a risk factor for the development of psychosis. There is lacked of literature on the link between risk factors such as brain injury and cannabis use in development of schizophrenia. Method: We reported a case with history of traumatic brain injury, who later developed schizophrenia like symptoms soon after initiation of cannabis uses. Further the symptoms persisted despite abstinence on cannabis but flared up after relapse of cannabis used. Results: Present case helps to understand common neurobiological mechanism behind schizophrenia and risk factors such as TBI and Cannabis abuse. Conclusion: Researches in this area are important for management and further understanding neurobiology of schizophrenia. ASEAN Journal of Psychiatry, Vol. 18 (1): January – June 2017: XX XX.