ABSTRACT
Background: Helicobacter pylori [H. pylori] is the main cause of gastroduodenal diseases, such as chronic atrophic gastritis, gastric ulcer [GU], and duodenal ulcer [DU]. There is a close relationship between H. or/-specific factors and different gastroduodenal diseases. The aim of the present study was to clarify the roles of the plasticity region genes [jhp0940, jhp0945, and jhp0947] and the known genes of cagPAI [cagA and cage] in relation to GU and DU diseases
Materials and Methods: A total of 173 strains that were isolated from 114 patients with non-atrophic gastritis [NAG], 30 patients with DU, and 29 patients with GU were genotyped. Data were collected and analyzed using SPSS software version 19.
Results: The cagE gene had the highest frequency [69.4%] and jhp0945 had the least frequency [11.0%] among the genes. When GU was considered as a dependant factor in simple logistic regression analysis, no genotype correlation was found with risk for GU in Iran [p>0.05]. Statistical analysis showed that cagA+ and cagAV jhp0940+ genotypes were significantly associated with an increased risk of DU but not GU. The Odds ratios [95% CI] were 3.143 [1.120-8.817], and 7.250 [1.493-38.199], respectively
Conclusion: Given the high frequency of cagE, this gene could be a suitable marker for the presence of cagPAI in Iranian strains. cagA[+] and cagAV jhp0940+genotypes can be beneficial biomarkers for risk prediction of DU in Iran