ABSTRACT
<p><b>AIM AND METHODS</b>Both PGE2 and cAMP are important neural mediator of fever. In order to discuss if PGE2 and cAMP are involved in the antipyretic mechanism of baicalin, fever models of rats were made by i.v. injection of endotoxin (ET). The antipyretic action and effects of baicalin on contents of PGE2 and cAMP in hypothalamus were observed.</p><p><b>RESULTS</b>Baicalin possessed obvious antipyretic effect on fever rats and reversed the effect of ET on contents of PGE2 and cAMP in hypothalamus. Correlation analysis showed that contents of PGE2 and cAMP in hypothalamus were positively correlated with the change of body temperature of rats.</p><p><b>CONCLUSION</b>Baicalin may exert its antipyretic effect on fever rats by inhibiting increase of contents of PGE2 and cAMP in hypothalamus.</p>