Pathological changes of arota in long-term pure hyperuricemia rat / 基础医学与临床

Objective To identify whether long-term hyperuricemia(HU)is able to induce arota pathological changes in rat.Methods 2%OA forage and 100 μmol/L uric acid plus OA lavage were used to copy a long-term hyperuricemia animal model,eNOS,ET-1,ICAM expression in arota was evaluated to find out the role of uric acid in cardiovascular diseases.Results The arotas of hyperuricemia rats had tiny damages whereas that of rats in con-trol group was totally normal; Hyperuricemia rat had less eNOS expression,more ET-1,ICAM expression in arota (P<0.05)and less NO,more ET-1,ICAM in serum.Conclusions Long-term hyperuricemia is able to induce im-pairment in endothelium in rat arota,but fails to cause atherosclerosis.