ABSTRACT
Objective To understand the characteristics of HIV infected persons without long term disease progress [also known as long term non-progressors (LTNPs)],and related factors in Guangxi Zhuang Autonomous Region (Guangxi).Methods Data of persons living with HIV and receiving no antiretroviral therapy in Guangxi by the end of 2016 were collected from the national HIV/AIDS comprehensive control and prevention information system of China.Results By the end of 2016,there were 313 LTNPs in Guangxi,accounting for 2.3 ％ of those being reported for more than 10 years,5.4％ of those being reported for more than 10 years and surviving,and 26.6％ of those being reported for more than 10 years,surviving and receiving no antiretroviral therapy.Among the LTNPs,87.2％(273) were men,94.9％ (297) were aged ≤ 40 years,32.3％ (101) were farmers,55.6％ (174) were single,divorced or widowed,69.3％ (217) were of Han ethnic group,68.1％ (213) were injecting drug users,and 52.1％ (163) were from custody facilities.Multiple logistic regression analysis indicated that factors associated with delayed disease progression included age ≤40 years (compared with age ＞40 years,aOR=1.55,95％ CI:1.31-3.12) and injection drug use (compared with sexual transmission,aOR=1.23,95％ CI:1.10-1.74).Conclusions A number of LTNPs existed in HIV-infected individuals in Guangxi.Further research are needed to identify the related factors,and it is necessary to conduct large sample size studies on host immunology,genetics and the virology of HIV to explore the related mechanism.
ABSTRACT
Objective To understand the characteristics of HIV infected persons without long term disease progress [also known as long term non-progressors (LTNPs)],and related factors in Guangxi Zhuang Autonomous Region (Guangxi).Methods Data of persons living with HIV and receiving no antiretroviral therapy in Guangxi by the end of 2016 were collected from the national HIV/AIDS comprehensive control and prevention information system of China.Results By the end of 2016,there were 313 LTNPs in Guangxi,accounting for 2.3 ％ of those being reported for more than 10 years,5.4％ of those being reported for more than 10 years and surviving,and 26.6％ of those being reported for more than 10 years,surviving and receiving no antiretroviral therapy.Among the LTNPs,87.2％(273) were men,94.9％ (297) were aged ≤ 40 years,32.3％ (101) were farmers,55.6％ (174) were single,divorced or widowed,69.3％ (217) were of Han ethnic group,68.1％ (213) were injecting drug users,and 52.1％ (163) were from custody facilities.Multiple logistic regression analysis indicated that factors associated with delayed disease progression included age ≤40 years (compared with age ＞40 years,aOR=1.55,95％ CI:1.31-3.12) and injection drug use (compared with sexual transmission,aOR=1.23,95％ CI:1.10-1.74).Conclusions A number of LTNPs existed in HIV-infected individuals in Guangxi.Further research are needed to identify the related factors,and it is necessary to conduct large sample size studies on host immunology,genetics and the virology of HIV to explore the related mechanism.
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Objective To establish the normal reference ranges of T lymphocyte subsets in healthy Zhuang ethnic minority across different age/ gender groups in Guangxi for providing the scientific guidance for clinical diagnosis and treatment evaluation of immunodeficiency diseases and viral infections as well as relat-ed researches. Methods Peripheral blood samples were collected from 405(196 male and 209 female) healthy subjects of Zhuang ethnic group including 82 adolescents and 323 adults. Single platform FACSCali-bur flow cytometry analysis was performed to detect the absolute counts of T lymphocyte subsets(CD45+, CD3+,CD4+ and CD8+)in peripheral blood samples. Results Reference ranges of T lymphocyte absolute counts in healthy Zhuang Chinese aged 14 to 59 were 2 377±696,1 503±459,802±253,581±243 and 1. 52±0. 57 for CD45+,CD3+,CD4+,CD8+ and CD4+ / CD8+. Significant differences in CD45+,CD3+ and CD8+ T lymphocytes were found between adolescents and adults(t = 0. 000,P﹤0. 05),but no significant difference in CD4+ T lymphocytes was observed between the two groups of people(t = 0. 373,P﹥0. 05). Significant difference between male and female groups was observed only in the absolute counts of CD8+ T lymphocytes(t= 0. 036,P﹤0. 05). The absolute counts of T lymphocyte subsets were on the decline along with the growth of the age. Conclusion This study indicates that the counts of T lymphocyte subsets vary with ethnic group,age and gender. Therefore,it is important to establish normal reference ranges of T lym-phocyte subsets for local healthy people based on gender and age for accurate evaluation of local patients' im-mune system status and treatment efficacy.
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ObjectiveTo investigate the ultrasonic clinical value of scalpel in abdominal surgery for D2 radical gastrectomy for gastric cancer.MethodsA retrospective analysis was made in Zhengzhou University Affiliated Luoyang Central Hospital from September 2008 to September 2010 gastric group.The patients were divided into ultrasound knife group and normal operative in 136,including 75 cases using ultrasonic scalpel,61 using cases electric knife.The lymph node dissection time,intraoperative blood loss,the drainage 72 h after were compared between the two groups.Results The average operation time ultrasound knife group was ( 114 ± 35 ) min,the surgery blood loss was ( 110.4 ± 32) mL.The drainage 72 h after operation was (180 ± 24) mL,which were significantly reduced compared with the normal operative group.The difference in detection rate between the two groups was not statric cancer can improve efficiency,reduce trauma,accelerate postoperative recovery,showing good application prospect in radical resection of gastri cancer.ConclusionsUltrasound knife used in D2 radical gastrectomy for gastric cancer can improve efficiency,reduce trauma,accelerate postoperative recovery,showing good application prospect in radical resection of gastric cancer.
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ObjectiveTo investigate the clinical value of CEA, CA19-9, CA242 and CA72-4 four serum tumor markers in colorectal cancer diagnosis, surgery and postoperative evaluation of their. Methods Immunohistochemical assay was used in 80 patients with colorectal cancer and 50 cases of colorectal benign diseases to detect the CEA, CA19-9, CA242 and CA72-4 and other four serum tumor markers, with 2-year follow- up. ResultsFour kinds of serum tumor markers CEA, CA19-9, CA242 and CA72-4 levels in colorectal cancer group were significantly higher than the control group ( P ＜ 0.05 ) ; levels of the four serum tumor markers in patients in Dukes stages C, D were significantly higher than those in Dukes stages A, B;four serum tumor markers were significantly increased in patients with recurrence of metastasis. Conclusion Combined detection of serum CEA, CA19-9, CA242 and CA72-4 has clinical value in diagnosis, surgical treatment evaluation and monitoring of metastasis and recurrence after surgery of colorectal cancer can improve detection sensitivity and specificity.