ABSTRACT
Objective: To investigate the effect of direct aspiration thrombectomy in treatment of middle cerebral artery M2 occlusion. Methods: Data of 8 patients with middle cerebral artery M2 occlusion who underwent direct aspiration thrombectomy were retrospectively analyzed. The vascular recanalization rate, intracranial hemorrhage 24 h after operation, National Institute of Health stroke scale (NIHSS) score before and 24 h, 14 days after thrombectomy, as well as the modified Rankin scale (mRS) score 90 days after thrombectomy were assessed. Results: Aafter thrombectomy, successful recanalization was obtained in all 8 cases, needing no other thrombectomy equipment nor technical remedies. No symptomatic intracranial hemorrhage occurred, while asymptomatic intracranial hemorrhage occurred in 3 patients. NIHSS scores gradually decreased 24 h and 14 days after operation. Ninety days after thrombectomy, good functional outcome with a mRS score ≤2 were achieved in all 8 patients, excellent functional outcome with a mRS score ≤1 was observed in 7 of them. Conclusion: Direct aspiration thrombectomy for middle cerebral artery M2 occlusion can improve neurological function of patients at an early stage with good efficacy and safety.
ABSTRACT
Metformin is a first-line drug for the treatment of type 2 diabetes mellitus. Recently, some clinical studies have been published reporting a reduced incidence of various neoplastic disease (eg. breast cancer, endometrial cancer and gastrointestinal cancer) in diabetic or nondiabetic patients treated with metformin. Metformin inhibits the mammalian target of rapamycin by activating liver kinase B1 (LKB1)/adenosine 5'-monophosphate-activated protein kinase (AMPK) or decreases blood insulin levels, resulting in inhibition of cancer cell growth. There are also many other mechanisms involved in anti-tumor effect of metformin. Although metformin has significant effect on cancers, the prospects for it as an alternative treatment modality and mechanism in various kinds of tumors need further research.
ABSTRACT
Objective To apply the oral gastrointestinal ultrasound contrast agents for evaluating the gastric motility abnor‐mality in the patients with anxiety disorder .Methods Twenty patients with anxiety disorder complicating upper digestive tract symptoms without organic pathological changes were enrolled as the anxiety disorder group .Twenty healthy volunteers were en‐rolled as the control group in this study .The two groups orally took gastrointestinal ultrasound contrast agents .The antral contrac‐tion frequency ,antral contraction amplitude amd MI were measured at each time point .GER was calculated .The the gastric motility parameters in the patients with anxiety disorder were evaluated .Results The antral contraction frequency and MI at initial 2 min had no statistical difference between the anxiety group and the control group .The antral contraction amplitude ,antral contraction frequency amd MI at each time point during 5 -10 min after contrast in the anxiety disorder group were significantly decreased compared with the control group ,and the differences were statistically significant (P< 0 .05) .After 20 min ,GER in the control group was significantly higher than that in the anxiety group ,the difference was statistically significant (P<0 .05) .Conclusion O‐ral gastrointestinal ultrasound contrast agents is a economic ,strongly operable ,non‐invasive and highly repeatable method for evalu‐ating the gastric motility .