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Objective To evaluate the influnce of atrial fibrillation(AF)/atrial flutter on the mortality and prognosis of patients with AMI. Methods A total of 297 consecutive patients were studied from Jan.2001 to Dec. 2005 and were categorized into 2 groups according to the presence or absence of AF/atrial flutter. The 30 d and 6 mo mortalities, Killip Grades, cardiogenic shock, arrhythmia and left ventricular ejectory functional (LVEF) 6 months after AMI with Doppler US between the 2 groups were compared. Results The incidence of AF/atrial fluttler was 12.5% with older age, higher Killip Gorade, higher CPK peak, higher rates of previous myocardial infarction and multivascular involvement than those without AF/atrial flutter. The short and medium-term mortalities in AF/atrial flutter group were both significantly higher than those of non-AF/atrial flutter group(P
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Objective:To investigate the changes of tumor necrosis factor ?(TNF?) expression and the relationship between TNF? and cardiac function during the progression of left ventricular remodeling in an experimental model of rat myocardial infarction(MI). Methods: Ninety male Sprague Dawley rats were randomly divided into sham-operated and MI groups. Rats in MI group were induced by ligation of the anterior descending coronary artery and were subdivided into 1 d,7 d,14 d,28 d and 42 d groups. Sham-operated animals underwent the same surgical procedure without ligation. Heart function and left ventricular remodeling were studied by echocardiography and hemodynamics. The expression of TNF? mRNA was assessed by reverse transcription-polymerase chain reaction. Results: From day 14 after operation,left ventricular end-diastolic diameter(LVEDD) began to increase in MI group,and fractional shortening(FS) and left ventricular ejection fraction(LVEF) began to decrease; both the increase and decrease reached the maximal on day 42 after operation. From day 1 after operation,left ventricular end-diastolic pressure(LVEDP) began to increase, and left ventricular(LV) pressure maximal rate of rise and fall (dp/dt_(max) and (dp/dtmin)) began to decrease; both increase and decrease reached the maximal on day 42 after operation. TNF? began to express on day 1 after MI, reached peak on day 7, and began to decrease thereafter; there was significant differences between MI group and sham-operated group.The expression of TNF? was positively correlated with LVEDD(r=0.94,P
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Objective To evaluate the effect of tranilast on neointimal proliferation and remodeling of rabbit iliac artery after balloon injury.Methods Twenty four rabbits were randomly divided into 3 groups including sham-operated group, control group, and treatment group. Balloon catheter was used to induce injury to the iliac artery of rabbits in control group and treatment group. Tranilast was given to the rabbits in treatment group (300 mg?kg -1) once a day from 3 days before operation to 28 days after operation, and then local vessels were harvested for pathological analysis and immunohistochemical staining. Automatic image analysis system was used to detect the changes of intimal thickness, medial thickness, luminal area, external elastic lamina (EEL) cross-sectional area and the proliferation index of proliferating cell nuclear antigen (PCNA). Results The intimal thickness was decreased in treatment group compared with control group. The luminal area and EEL cross-sectional area were significantly larger in treatment group than those in control group. No significant difference was found between treatment group and control group in medial thickness. The proliferation index of PCNA was significantly reduced in treatment group compared with control group. Conclusions Tranilast signifcantly inhibited neointimal hyperplasia and prompted compensatory artery dilation during remodeling of rabbit iliac artery after balloon injury. The effect on neointimal hyperplasia may be partly attributed to the inhibition of vascular smooth muscle cell proliferation.