ABSTRACT
Introduction: Glaucoma is an idiopathic, progressive optic disc neuropathy complicating into irreversible blindness if untreated. Early diagnosis by screening cases from high-risk populations has a pivotal role in managing this major public health problem with high treatment expenditures. Objectives: To identify the various ocular and non ocular risk factors of glaucoma and to identify the drug prescription pattern among glaucoma patients. Method: This was an observational, case-control study including 165 adult Glaucoma patients on treatment as cases and 165 age and sex-matched healthy individuals as controls, all of which were randomly selected from the patients visiting a tertiary eye care center. Various risk factors, drug prescription pattern and symptoms of the patients were recorded and analyzed. Results: A total of 165 adult Glaucoma patients and age and gender matched 165 controls were enrolled. Majority of the patients (41.21%) complained of blurring of vision at the time of study. The Odds ratios for Family history, Hypertension, Diabetes Mellitus, Migraine, Sleep apnea and Smoking showed strong association as risk factors for Glaucoma and the differences between the two groups were statistically significant (p value < 0.05). The mean number of drugs per prescription ± SD was 1.88 ± 0.79. Fixed drug formulations were prescribed in 42.4% patients. All the drugs were prescribed by their brand names and majority of them were in the form of eye drops. Conclusion: Primary Open Angle Glaucoma (POAG) was the most common subtype in the study. Age, Family history, Myopia, Hypertension, Diabetes Mellitus, Sleep Apnea, Migraine, Corticosteroid usage and Smoking emerged as putative risk factors. In consistence with present guidelines, Prostaglandin analogs were the most prescribed antiglaucoma drugs. The considerable proportion of asymptomatic cases (23%) suggests the need for periodic eye examinations to detect glaucomatous changes at an early stage.
ABSTRACT
Background: Substance abuse has emerged as a global phenomenon and prevalent throughout the world in all the cultures. Abuse of alcoholic beverages and tobacco are endemic in many societies, whilst the abuse of other psychoactive substances is growing concern in India. It has major impact on physical, psychological, social and environmental aspect of life.Methods: A cross sectional study was carried out amongst 100 persons attended at Mind Care de-addiction centre, Ahmedabad during the period of 1st January to 28th February 2018 with the help of pretested semi structured questionnaire.Results: Majority of the substance abusers were males (98%) and within the age group of 31 to 45 years (46%). Out of total abusers 28% were graduate and 47% doing skilled work. Majority of study participants were married (47%), belong to joint families (92%) and belongs to socio economic class I and II (50%). Most commonly used drug was alcohol (64%), followed by tobacco (20%), cannabis (12%) and opium (4%). Majority of users started to use it for social reasons (33%) and stress (26%). They got it for the first time from friends in 62% cases and 36% got by themselves. Health related changes were experienced in more than 50% of cases. Out of them, 84% feel improvement after visiting the centre.Conclusions: Drug use pattern is ever changing and has emerged as a global burden as it causes serious public health problems. There is a felt need for the assessment of the evolving trends of substance abuse. And suitable interventions for primary prevention should be considered.