ABSTRACT
Objective To study the application value of T lymphocyte subsets and inflammatory factors in evaluating severity andprognosisofaplasticanemia.Methods 40patientswithaplasticanemiainthehospitalwereenrolledinthestudyasAAgroup, which was further divided into acute aplastic anemia(AAA) subgroup and chronic aplastic anemia(CAA) subgroup .In addition to that ,40 healthy people who received physical examination in the hospital during the same period were enrolled in the study as con‐trol group .Then blood routine tests were performed ,T lymphocyte subsets content in peripheral blood and serum inflammatory fac‐tor content were detected and the results were compared .Results Th1 ,Th17 contents and Th1/Th2 ,Th17/Treg ratio in AA group were higher than those in control group(P<0 .05) ,while Th2 ,Treg contents were lower(P<0 .05);Th1 ,Th17 contents and Th1/Th2 ,Th17/Treg ratio in AAA group were higher than those in CAA group(P<0 .05) ,while Th2 ,Treg cells contents were lower . Serum IL‐2 ,IFN‐γ ,IL‐17 contents in AA group were higher than those in control group(P<0 .05) ,while IL‐4 ,IL‐6 ,IL‐10 contents were lower(P<0 .05);serum IL‐2 ,IFN‐γ,IL‐17 contents in AAA group were higher than those of CAA group ,while IL‐4 ,IL‐6 , IL‐10 contents were lower .Hb ,PTL contents were negatively correlated with Th1 ,Th17 contents and serum IL‐2 ,IFN‐γ ,IL‐17 contents ,while positively correlated with Th2 ,Treg cells contents and serum IL‐4 ,IL‐6 ,IL‐10 contents .Conclusion Peripheral blood T lymphocyte subsets and serum inflammatory factors contents in aplastic anemia are abnormal and are correlated with the severity and prognosis related indicators .
ABSTRACT
Objective To study the levels of serum homocysteine(Hcy) ,high-sensitivity C-reactive protein (hs-CRP) and blood lipid and their correlation in the different age stage patients with cerebral infarction .Methods 352 patients with cerebral infarction receiving treatment in the hospital from December 2011 to November 2013 were selected as the study subjects and divided into the youth group ,middle age group and elderly group by age ,with contemporaneous 134 healthy individuals of physical examination as the control group .Serum lipids ,hs-CRP ,Hcy levels and the rate of abnormal test results were compared among 4 groups and the bi-variate correlation analysis was performed .Results The serum hs-CRP ,Hcy levels in the youth group were higher than those in the control group ,while the high density lipoprotein cholesterol(HDL-C) level was lower than tha tin the control group ,the difference was statistically significant (P<0 .05) .The serum low density lipoprotein cholesterol(LDL-C) ,total cholesterol (TC) ,hs-CRP and Hcy levels in the middle age and the elderly groups were significantly higher than those in the control group ,while the HDL-C level was significantly lower than that in the control group ,the difference was statistically significant (P<0 .05) .The abnormal rates of HDL-C ,hs-CRP and Hcy test results in the youth ,middle and elderly groups were significantly higher than those in the control group with statistical difference (P< 0 .05) .The abnormal rates of LDL-C detection results in the middle age group and elderly group were significantly higher than that in the control group ,the difference was statistically significant (P<0 .05) .Hcy ,hs-CRP and lipid in the youth group ,middle group and elderly group had no significant correlation ;HDL-C was negatively correlated with hs-CRP (P<0 .05);TC was positively correlated with LDL-C ,HDL-C and triglyceride(P<0 .05) .Conclusion Hyperhomocys-teinemia is an independent risk factor for cerebral infarction occurrence ,has no significant correlation with blood lipid and hs-CRP levels ,and can be used as a reliable indicator of the disease condition monitoring .