ABSTRACT
<p><b>OBJECTIVE</b>To assess the role of oxidative metabolism and nitric oxide synthesis for elucidating their pathophysiological mechanisms in a Tibetan patient with essential hypertension.</p><p><b>METHODS</b>The serum levels of total superoxide dismutase (T-SOD), malondialdehyde (MDA), total antioxidant capacity (T-AOC), nitric oxide (NO) and nitric oxide synthase (NOS) were assayed in sixty native Tibetans (thirty hypertensive patients and thirty healthy volunteers as control).</p><p><b>RESULTS</b>The levels of T-SOD, T-AOC, NO and NOS were significantly lower in the patient group than in the control group (P < 0.01); MDA was significantly higher in the patient group than in the control group (P < 0.01). The level of MDA had a strong negative correlation with T-SOD, T-AOC, NO and NOS (r = -0.82, -0.76, -0.79, -0.73, respectively, P < 0.001 for all).</p><p><b>CONCLUSION</b>Tibetan patients with essential hypertension (EH) may have underlying oxidative metabolism dysfunction and depressed NO synthesis, both responsible for the hypertensive process.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Altitude , Endothelium, Vascular , Physiology , Hypertension , Nitric Oxide , Oxidation-Reduction , TibetABSTRACT
ObjectiveTo discuss problems derived from operative treatment for liver echinococcosis.MethodEighty cases of vesiclectomy with different additional procedures were reviewed with respect to their efficacy or complication. ResultsThere was no mortality in all the patients undergoing various operations. Abscess developed in 6 out of 26 cases undergoing simple vesiclectomy. Two out of 52 cases undergoing "vesiclectomy coupled with tube drainage" suffered bile leakage, while there was no complication in 2 cases undergoing "vesiclectomy plus Roux en Y type vesicajejunostomy". ConclusionVesiclectomy plus tube drainage is the procedure of choice for the treatment of liver echinococcosis.