ABSTRACT
Objective To evaluate the effect of a new adjuvant preoperative and postoperative chemotherapy on patients with rectal cancer.Methods 113 patients with rectal cancer consisted of two groups: T group (n=55), 5 Fu (5 fluorouracil)10 20 ml,keep down clysis qn,for ten times before opretion.5 Fu 500 mg/ m 2 ,CF(Leucovorin) 30mg/m 2 or 300 mg/m 2,iv qd for five times one week after operation;C group(n=58), 5 Fu 500 mg/m 2,iv.for five times befor surgery.5 Fu 500 mg/m 2 iv qd for five times one week after surgery.Results 3 years surivival rates,the counts of WBC. 16pc.were not statistically different between two groups.But 5 years surivival rates,the recurrence rates and infection rates postopretion of patients were statistical different. Conclusion 5 Fu keep down clysis pre opretion and 5 Fu/CF iv. postopretion can increase 5 years surivival rates and decrease recurrence rates of patients were with rectal cancer.