ABSTRACT
Objective To observe safety and efficacy of intrauterine device MYCu IUD that releases indomethacin. Methods In total, 2000 women requiring IUD for contraception were chosen from domestic multiple clinical centers according to an unified standard. MYCu IUD and TCu380A IUD were randomly inserted for 1000 women each, respectively. All women were regularly followed-up one, three, six and 12 months after insertion. Results All the women were followed-up for 11 985.9 and 11 753.6 person-months in MYCu IUD and TCu380A IUD groups, respectively, with cumulative IUD application rates of 97. 80% and 94. 70%, and cumulative pregnancy rates with IUD of 0. 10% and 0. 31%, respectively. Cumulative expulsion (or partial expulsion) rate in MYCu IUD group was 0. 10%, significantly lower than that in TCu380A IUD one (1.73%), P ＜0. 01, and cumulative removal rate due to medical reasons (bleeding or pain) was 1.51 % and 2. 94%, respectively, P ＜ 0. 05. Rate of IUD-associated termination and overall rate of termination differed significantly between the two groups, P ＜0. 01. Adverse reactions one, three, six and twelve months after IUD insertion included irregular bleeding, prolonged menstruation, increased menstrual blood volume and pain, less in indomethacin-containing MYCu IUD group than those in TCu380A IUD without containing it, P ＜ 0. 01. Conclusions MYCu IUD is a comparatively ideal IUD that should be promoted for extensive use, with extremely low expulsion rate, good contraceptive effect, convenience and safety in insertion and removal, and less adverse effects.
ABSTRACT
ObjectiveTo explore the influence of Gaoyu ankang capsule on the water load of ent rants landing at high altitude rapidly and its significance. Methods 80 soldiers who went from plain to high altitude by air for the first time were randomly divided into, experi mental group and control g roup. Experimental group was asked to orally take 2 granules of Gaoyuankang capsule 3 times per day for 3 days before boarding a plane. Control group was not given any pharmaco-prevention. Water load experiment was performed at the fi rst day before and at the third day after landing at high altitude in the tw o groups. Urine quantity of two groups was recorded and compared at various time points in 150 minutes after water was given. Results Urine quantity at each time points in 61～150 minutes after water load experiment beginning and total urine quantity i n corresponding time points remarkably de creased in the control group after landing at high altitude(P