ABSTRACT
Context: Oral health is a fundamental aspect of general health which significantly affects quality of life (QoL) of an individual. Oral health-related QoL is a multidimensional concept determined by race, education, culture, and experiences related to oral diseases. Aim: This study aims to evaluate the Hindi (Indian) version of the child perceptions questionnaire (CPQ11-14) among 11–14-year-old school children in Rohtak City, Haryana, India. Materials and Methods: A cross-sectional study was carried out among 586 children in Rohtak city, Haryana, India, to find out the translation and cross-cultural adaptation of CPQ11-14. The original version of CPQ11-14was translated to Hindi language, and the dental caries experience was measured by caries assessment spectrum and treatment index. Statistical Analysis: The data were entered into Microsoft Excel and analyzed using SPSS 18. Reliability was assessed in 2 ways: internal consistency reliability and test-retest reliability. The level of significance was set at 0.05. Results: Construct validity was confirmed demonstrating statistically significant associations between total CPQ11-14 score and global ratings of oral health (P = 0.00) and overall well-being (P = 0.00). Mean CPQ11-14scores (20.30 ± 10.91) including all the domain scores were higher among children without dental caries when compared to children with dental caries (19.79 ± 9.88) and the instrument was not able to discriminate between two clinical groups significantly (P = 0.08). Conclusion: The Hindi version of the CPQ11-14 questionnaire is a reliable instrument having good reliability, good construct, and convergent validity but lacks discriminant validity. Shorter forms of CPQ11-14may be more useful when compared to original construct.
ABSTRACT
The present study was designed to assess and compare parenting stress and family burden in mothers of children with disabilities and children without disability. For this purpose, a multi group design was adopted which consisted of five groups of mothers viz. mothers of children with mental disability, mothers of children with both mental and physical disability, mothers of children with physical disability, mothers of deaf and dumb children and mothers of children without disability. Parenting stress index and family burden scale were administered on 125 mothers of children with disabilities and without disability (25mothers in each group), selected from three districts of Haryana state. For statistical analysis, t- test, simple analysis of variance and Duncan‟s post hoc test were used. Results revealed that mothers of children with both mental and physical disability and mothers of children with mental disability scored significantly higher level of parenting stress and family burden compared to mothers of children with physical disability, mothers of deaf and dumb children, and mothers of children without disability.
ABSTRACT
Objective: In an effort to etablish new candidates with improved antineoplastic activity, 4-cycloalkylidineamino 1,2-naphthoquinone semicarbazones were synthesized, characterized and evaluated for anticancer activity. Method: The desired compounds were synthesized by condensation of 4- amino1, 2-naphthoquinone with cyclic ketones and further subsequent reaction of this product with semicarbazide hydrochloride. Compounds were characterized by FT-IR, 1H NMR, 13C NMR, elemental analysis and screened for antiproliferative activity against three human cancer cell lines (HepG2, MG-63 and MCF-7) by MTT assay using doxorubicin as standard. Docking was performed by using the Glide 5.7 integrated with Maestro 9.2 (Schr?dinger, LLC, 2011) to understand the binding preference of synthesized compounds with target enzyme topoisomerase-II. Results: 4-(cyclohexylideneamino) [1, 2] naphthoquinone 2-semicarbazone was found to be most active cytotoxic agent against all cancer cell lines with IC50 values in the range of 5.58–6.31 μM. Results of molecular docking were also well correlated in vitro cytotoxicity assay. Insilico ADME studies revealed the drug likeliness of compounds. Conclusions: The synthesized compounds were found to have significant anticancer activity and able to enter in higher phases of the drug development process due to favorable pharmacokinetic properties.