Synthesis, spectral and antimicrobial studies of some transition metal(II) complexes with schiff base 3-[(2-Hydroxy-6-Methoxyquinolin-3- Ylmethylene)-Amino]-2-Methyl-3h-Quinazoline-4-One.

The Complexes of the type ML2 and M¢L [where M= Cu(II), Co(II), Ni(II) and Mn(II); M¢= Zn(II), Cd(II) and Hg(II)] with the Schiff base ligand (HMeOQMAMQ) L=3-[(2-hydroxy-6-methoxyquinolin-3-ylmethylene)- amino]-2-methyl-3H-quinazoline-4-one, have been synthesized. Their characterizations have been done by elemental analysis, conductance data, magnetic susceptibility measurements, 1H NMR, electronic, IR, ESR and X-ray studies. Ligand field parameters of some of the complexes have also been calculated. On the basis of spectral studies, the complexes of Zn(II), Cd(II) and Hg(II) have been assigned tetrahedral geometry, where as complexes of Co(II), Ni(II) and Mn(II) have been assigned octahedral geometry, The complex of Cu(II) has been assigned distorted octahedral geometry. The Schiff base ligand and its complexes have also been screened for their antimicrobial activity against selected fungi and bacteria. The antimicrobial results indicate that the metal complexes act as better antimicrobial agents as compared to the Schiff base ligand.

Trichotillomania.

Trichotillomania is one of the types of traumatic alopecia and is defined as the irresistible urge to pull out the hair, accompanied by a sense of relief after the hair has been plucked. In trichotillomania alopecia results from deliberate efforts of the patients who is under tension or is psychologically disturbed. The condition maybe episodic and the chronic type is difficult to treat. The prevalence of the condition appears to be more common than previously believed. The purpose of this article is to discuss the various aspects of the condition including the available treatments.

Dry skin conditions, eczema and emollients in their management.

Dry skin, which refers to roughened, flaky, or scaly skin that is less flexible than normal and dry to feel, is relatively common problem in all age groups, but is more common in elderly individuals. The water content of the stratum corneum is of paramount importance in maintaining the normal appearance and texture of human skin. The relative hydration of the stratum corneum is a composite of 3 factors viz. the rate of water transport from dermis to stratum corneum, the rate of surface loss of water and the rate of water binding ability of stratum corneum. Loss of integrity of the barrier function is a central factor in the development of dry skin conditions and eczema. The various factors involved in producing dry skin, various causes of dry skin and the role of emollients in the management of these conditions are discussed.

Cutaneous and mucosal pain syndromes.

The cutaneous and mucosal pain syndromes are characterized by pain, burning sensation, numbness or paraesthesia of a particular part of the skin or mucosal surface without any visible signs. They are usually sensory disorders, sometimes with a great deal of psychologic overlay. In this article various conditions have been listed and are described. The possible causative mechanisms are discussed when they are applicable and the outline of their management is described.

Calcification of ulnar nerve in a patient with tuberculoid leprosy--a case report.

A case of Tuberculoid Leprosy who showed Evidence of Calcification of Right Ulnar Nerve at Elbow on Radiological Examination is reported.

Correlation of clinical and histopathologic features in untreated macular lesions of leprosy--a study of 100 cases.

Clinical and histopathological correlative studies carried out in 100 cases of leprosy with macular lesions revealed an overall parity in 47% of the cases. Disparity was observed in TT, BT, BB, BL and IL series but not in LL series. The variable tissue response in the disease spectrum due to the variability of CMI is responsible for the disparity in various types of leprosy, irrespective of the type of lesions, whether macular or elevated.