ABSTRACT
The aim of this study was to evaluate the effects of single oral doses of D-005 (a lipid extract obtained from the fruit oil of Acrocomia crispa) on LPS-induced acute lung injury (ALI) in mice. D-005 batch composition was: lauric (35.8%), oleic (28.4%), myristic (14.2%), palmitic (8.9%), stearic (3.3%), capric (1.9%), caprylic (1.2%), and palmitoleic (0.05%) acids, for a total content of fatty acids of 93.7%. D-005 (200 mg/kg) significantly reduced lung edema (LE) (≈ 28% inhibition) and Lung Weight/Body Weight ratio (LW/BW) (75.8% inhibition). D-005 (25, 50, 100 and 200 mg/kg) produced a significant reduction of Histological score (59.9, 56.1, 53.5 and 73.3% inhibition, respectively). Dexamethasone, as the reference drug, was effective in this experimental model. In conclusion, pretreatment with single oral doses of D-005 significantly prevented the LPS-induced ALI in mice.
El objetivo de este estudio fue evaluar los efectos de dosis orales uÌnicas de D-005 (extracto lipiÌdico obtenido del aceite de frutos de Acrocomia crispa) sobre el danÌo pulmonar agudo (DPA) inducido por LPS en ratones. La composicioÌn del lote de D-005 fue: aÌcido laÌurico (35.8%), oleico (28.4%), miriÌstico (14.2%), palmiÌtico (8.9%), esteaÌrico (3.3%), caÌprico (1.9%), capriÌlico (1.2%) y palmitoleico (0.05%), con un contenido total de aÌcidos grasos de 93.7%. D-005 (200 mg/kg) redujo significativamente el edema pulmonar (EP) (≈ 28% de inhibicioÌn) y la relacioÌn peso pulmoÌn/peso corporal (PP/PC) (75.8% de inhibicioÌn). D-005 (25, 50, 100 y 200 mg/kg) produjo una reduccioÌn significativa de la puntuacioÌn histoloÌgica (59.9, 56.1, 53.5 y 73.3% de inhibicioÌn, respectivamente). La dexametasona, faÌrmaco de referencia, fue efectiva en este modelo experimental. En conclusioÌn, el pretratamiento con dosis orales uÌnicas de D-005 previno significativamente el DPA inducido por LPS en ratones.
Subject(s)
Animals , Mice , Plant Extracts/administration & dosage , Arecaceae , Acute Lung Injury/prevention & control , Plant Extracts/chemistry , Lipopolysaccharides/adverse effects , Administration, Oral , Chromatography, Gas , Acute Lung Injury/chemically induced , Fatty Acids/analysis , Fruit , Lung/drug effectsABSTRACT
This study was aimed to investigate whether the a lipid extract from Acrocomia crispa fruits (D-005) inhibits COX and 5-LOX enzyme activities in vitro. This study demonstrates that D-005 inhibits markedly and in a dose dependent manner COX-2 and 5-LOX activities. The dual inhibition of COX-2 and 5-LOX supports further research on the potential anti-inflammatory effect of D-005.
El objetivo de este estudio fue investigar si el extracto lipídico de los frutos de Acrocomia crispa (D-005) inhibe in vitro las actividades de las enzimas COX y 5-LOX. Este estudio demuestra que el D-005 inhibe marcadamente y de manera dosis dependiente las actividades de la COX-2 y 5-LOX. La inhibición dual de la COX-2 y 5-LOX soportan futuras investigaciones sobre el potencial efecto anti-inflamatorio del D-005.