ABSTRACT
One patient with congenital epidermolysis bullosa combined with pachyonychia was reported, and followed up for 11 years. The pedigree of the patient was investigated, and the loci of HLA-A, B antigens of 16 members of the pedigree were determined. The results showed that there were 60 members in the pedigree, among them 24 members had different kinds of skin diseases : 4 cases of epidermolysis bullosa combined with pachyonychia, 9 eases of albopapuloid form of epidermolysis hullosa combined with pachyonychia, 2 cases of icthyosis and 9 cases of pachyonychia simplex. The result of HLA-A, B antigens analysis of 16 members of the pedigree showed no evidence of the genes of these patients linked with HLA-A, B antigens.
ABSTRACT
Shenqi mixture tonic (C. A. mixture )is a compounded Chinese herb preparation composed of Codnopsis pilosula (Franch. )Nannf., Astragalus membranaceus Bge. and Polygonum multiflorum Thunb. Its antiaging effect was studied on 24 months old SD rats. The body weight, food intake,cardiac capacity and activities ofbrain monoamine oxidase-B(MAO-B)and red blood cell superoxide dismutase (SOD)were estimated to assess its antiaging effect. Results indicated that after feeding C. A. mixture for a fixed time the activity of MAO-B was decreased and that of red blood cell SOD increased obviously. Calorie production and cold resistant capabbility of the aged animals were improved significantly though there were no gain in body weight. In addition ,the cardiac capacity was enhanced. From the above results it can be concluded that C. A. mixture possesses evident antiaging effect